Results 41 to 50 of about 6,561,659 (253)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

El autor científico

open access: yesRevue d'anthropologie des connaissances, 2010
This presentation connects the developments of Science Studies to those of scientific discourse analysis. Science Studies has come to pay more attention to the concrete situations in which science is elaborated in the laboratory, which is a kind of ...
Francis Grossmann
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Annotating discourse connectives by looking at their translation: The translation-spotting technique [PDF]

open access: yes, 2013
The various meanings of discourse connectives like while and however are difficult to identify and annotate, even for trained human annotators. This problem is all the more important that connectives are salient textual markers of cohesion and need to be
Cartoni, Bruno   +2 more
core   +3 more sources

O discurso pedagógico da ciência em operação na Rede Nacional de Educação e Ciência: Novos Talentos da Rede Pública (RNEC/NT)

open access: yesCiência & Educação
Resumo Este artigo objetiva analisar como alguns grupos da Rede Nacional de Educação e Ciências: Novos Talentos da Rede Pública (RNEC/NT), da região sul do país, operam o que temos chamado discurso pedagógico da ciência em cursos para professores e ...
Lavínia Schwantes   +2 more
doaj   +1 more source

“Knowledge vendors” and “alms-askers”: studying scientific and political discourse in Anglo-American and Russian socio-humanities

open access: yesSHS Web of Conferences, 2016
This article analyzes the interaction and mutual influence of the discourse of science and the public authorities in modern Russian and Anglo-American socio-humanities.
Bkeikher Oksana   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

THE DISCOURSE OF THE EPISTEMIC COMMUNITY OF ARTISTIC GYMNASTICS: THE ANALYSIS OF ARTICLES' TITLES

open access: yesScience of Gymnastics Journal, 2009
The goal of this study was to analyse 105 titles of articles published in 43 journals that are indexed in at least one of the three databases - ScienceDirect, MEDLINE and Scopus - in order to describe the epistemic community that deals with gymnastics ...
Darija Omrčen   +1 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

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