Results 31 to 40 of about 11,994,000 (257)

On assessing the viral safety of individual units of the substance "Human plasma for fractionation" by nucleic acid amplification

Биопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. The absence of blood-borne viruses in human plasma-derived medicinal products must be ensured by the control of raw materials and the manufacturing process.Aim.
E. V. Elbert, V. V. Nozhko, R. A. Volkova, A. A. Movsesyants, V. A. Merkulov, V. V. Kosenko   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Mycoplasma - contamination of cell cultures

Биопрепараты: Профилактика, диагностика, лечение, 2018
The safety of biological products derived from animal cells is associated with the properties of the cells themselves or their components, as well as with the possible presence of contaminants of microbial and viral origin.
N. V. Shalunova, R. A. Volkova, A. R. Volgin, E. M. Petruchuk, Z. E. Berdnikova, E. V. Elbert, V. A. Shevtsov, A. V. Rukavishnikov, I. S. Semenova, O. V. Merkulova, G. A. Trusov, N. V. Tereshkina, O. A. Rachinskaj, I. N. Indikova, E. V. Lebedinskaya, E. D. Mytsa   +15 more
doaj  

International standards for monoclonal antibodies for assessing the biological activity of medicines: A status update

Биопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. The clinical effects and the expiration of patents for original (reference) biotechnological medicines based on monoclonal antibodies (mAbs) stimulated the development of biosimilar mAbs.
L. A. Gayderova, N. A. Alpatova, S. L. Lysikova, M. L. Baykova, A. M. Guskov, D. A. Zubkov   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Evaluation inventory

, 2012
French version available in IDRC Digital Library: Répertoire des rapports d’évaluationThis guideline provides instructions on how researchers and awardees can access IDRC evaluation reports and how to submit their own to LiveLink in order to keep the ...
IDRC. Evaluation Unit
core   +1 more source

Topical issues related to reference standards in the sphere of circulation of biological products

Биопрепараты: Профилактика, диагностика, лечение, 2018
Pharmacopoeial analytical methods involving reference standards (RS) are used for manufacture and quality control of medicinal products, including biologicals, these RS should now to be called pharmacopoeal.
R. A. Volkova, O. V. Fadeikina, V. I. Klimov, E. I. Sakanyan, Yu. V. Olefir, V. A. Merkulov, A. A. Movsesyants, V. P. Bondarev, I. V. Borisevich, D. V. Shvedov   +9 more
doaj  

Using Real-Time RT-PCR Reagent Kits for Identity Testing of Measles, Mumps and Rubella Vaccines

Биопрепараты: Профилактика, диагностика, лечение, 2018
Currently, the identity of measles, mumps and rubella virus vaccines is determined during certification testing by a labour-consuming, lengthy and costly neutralisation test using cell cultures.
A. S. Binyatova, E. D. Mytsa, N. V. Chertova, R. A. Volkova, K. A. Sarkisyan, T. N. Ilyasova, T. N. Yunasova, A. A. Movsesyants, V. A. Merkulov   +8 more
doaj   +1 more source

Current Requirements for the Degree of Fineness of Herbal Substances and Herbal Medicinal Products

Регуляторные исследования и экспертиза лекарственных средств, 2020
The introduction of monographs on new types of herbal substances, which were not included in the previous editions of the State Pharmacopoeia of the Russian Federation (Ph.
E. L. Kovaleva, V. V. Shelestova, L. N. Frolova, O. V. Bondarenko, O. B. Nikolaeva, V. Yu. Kuteynikov   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source