Results 111 to 120 of about 44,866 (295)

Inexpensive DIY Magnetometer Designs for Formal and Informal Investigations of Geomagnetic Sq Variations and Space Weather Events

IEEE Access
Simple magnetometers are the gateway instruments for exploring the geomagnetic field that can be used by hobbyists and teachers alike to monitor and study a variety of space weather phenomena.
Sten Odenwald, Hilarie Davis, Christina Milotte, Cris L. DeWolf   +3 more
doaj   +1 more source

Creation of the environment of the scientific applications implementation in the Grid with the use of GridSphere and Vine Toolkit as part of an integrated scientific gateway

, 2012
Запропоновано метод реалізації виконання наукових додатків у Грід-середовищі в межах комплексного наукового шлюзу, який побудовано з використанням GridSphere та Vine Toolkit. Наведено модель архітектури такого наукового шлюзу.
Романюк, О.М., Сапігора, А.С., Марченко, О.І., Свістунов, С.Я.   +3 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Management and Deployment of Scientific Applications with SIMULOCEAN Science Gateway

, 2017
SIMULOCEAN is a web-based scientific application and visualization framework for the management and deployment of software serving the coastal modeling community. The framework helps to collect observational data, schedule modeling codes for execution, manage data transfer, and visualize both observational and numerical results.
Tao, Jian, Jin, Du, Huasong Shan, Wong, Mona, Zonca, Andrea, Q. Jim Chen   +5 more
openaire   +1 more source

Scientific Social Objects: The Social Objects and Multidimensional Network of the myExperiment Website

Scientific research is increasingly conducted digitally and online, and consequently we are seeing the emergence of new digital objects shared as part of the conduct and discourse of science.
De Roure, David, Newman, David, Goble, Carole, Bechhofer, Sean   +3 more
core  

How to Position Your Gateway for Failure: The Ten Don’ts of Gateway Design

How to Position Your Gateway for Failure:The Ten Don’ts of Gateway DesignAbstractScience gateways are accelerators for science and education, providing user-friendly access to powerful computational resources and data analysis tools.
Brandt, Steven, Bradley, Shannon, Villegas Martinez, Braulio M., Kee, Kerk, Gesing, Sandra, Cleveland, Sean, Smith, Jack   +6 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Demonstration of Unidata Science Gateway

, 2020
With the goal of better serving our community, Unidata is investigating how its technologies can best make use of cloud computing. The observation that science students and professionals are spending too much time distracted by software that is difficult
Julien Chastang (640650)
core   +1 more source