Results 121 to 130 of about 44,866 (295)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
External views of the Science Gateway complex
, 2023 Science Gateway will open its doors in October this year. It will be a new facility for scientific education and outreach. Aimed at engaging audiences of all ages, the building will include inspirational exhibition spaces, laboratories for hands-on ...
Cavazza, Marina
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The IIASA TPA/70 - X.25 Gateway Network Promotes International Flow of Scientific Information
, 1982 This paper describes the "TPA/70-X.25 gateway-network" of the International Institute for Applied Systems Analysis (IIASA)in Austria, and of the Institute for Computerization and Automation of the Hungarian Academy of Sciences (SZTAKI) in Hungary, and ...
Labadi, A., Sebestyen, I.
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Public Health ResearchBackground Young adults represent a third of the United Kingdom prison population and are at risk of poor health outcomes, including drug and alcohol misuse, self-harm and suicide.
Alison Booth +13 more
doaj +1 more source
Applied SciencesGases are prone to accumulating in mines. Untimely gas drainage can easily trigger gas outbursts, which may further lead to gas explosions, directly endangering personnel lives and mine safety.
Haibin Wang +5 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The development of an integrated process operation management system
, 2004 This project details the development of a new framework known as the Coordinated Knowledge Management method to enable complete task integration of all low and midlevel tasks for process industries.
Power, Yvonne
core