Results 81 to 90 of about 44,866 (295)

The “Gateway Belief” illusion: reanalyzing the results of a scientific-consensus messaging study [PDF]

Journal of Science Communication, 2016
This paper analyzes data collected but not reported in the study featured in van der Linden, Leiserowitz, Feinberg, and Maibach [van der Linden et al., 2015]. VLFM report finding that a “scientific consensus” message “increased” experiment subjects' “key beliefs about climate change” and “in turn” their “support for public action” to mitigate it ...
openaire   +2 more sources

VIALACTEA science gateway for Milky Way analysis [PDF]

, 2019
This paper presents the latest developments on the VIALACTEA Science Gateway in the context of the FP7 VIALACTEA project. The science gateway operates as a central workbench for the VIALACTEA community in order to allow astronomers to process the new ...
Costa, A., DI GIORGIO, Anna Maria, Hajnal, A., Di Giorgio, A. M., Ugo Becciani, Stefano Cavuoti, Schisano, E., Riccio, G., Massimo Brescia, Becciani, U., Scige John Liu, VITELLO, FABIO ROBERTO, Istvan Marton, Zoltan Farkas, LIU, Scige' John, Eva Sciacca, ELIA, Davide Quintino, Elia, D., COSTA, Alessandro, Kacsuk, P., Molinari, S., Brescia, M., Alessandro Costa, Liu, S. J., Sciacca, E., Sergio Molinari, Anna Maria Di Giorgio, Peter Kacsuk, CAVUOTI, STEFANO, Marton, I., Davide Elia, Farkas, Zoltan, Marton, Istvan, MOLINARI, Sergio, Vitello, F., Fabio Vitello, RICCIO, GIUSEPPE, Giuseppe Riccio, Cavuoti, S., Hajnal, Akos, Eugenio Schisano, Kacsuk, Peter, SCIACCA, Eva, Farkas, Z., SCHISANO, EUGENIO, Akos Hajnal, BRESCIA, Massimo   +46 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Gateway cities [PDF]

, 2016
Chua et al. (2014) define an Antarctic gateway port as a coastal or island port, able by its proximity to the Antarctic to benefit from, and control access to, Antarctic and Southern Ocean resources, including fishing, tourism and scientific support ...
Turnbull, Morag, Sima, Ellen, Chambers, Claire, Laubscher, Laetitia, Chen, Xu   +4 more
core  

Improvements of the UltraScan scientific gateway to enable computational jobs on large-scale and open-standards based cyberinfrastructures

, 2013
The UltraScan data analysis application is a software package that is able to take advantage of computational resources in order to support the interpretation of analytical ultracentrifugation (AUC) experiments.
Borries Demeler, Gunathilake, Lahiru, Raminder Singh, Riedel, Morris, Gorbet, Gary, Thomas Lippert, Demeler, Borries, Gary Gorbet, Suresh Marru, Florian Janetzko, Norbert Attig, Marru, Suresh, Morris Riedel, Grimshaw, Andrew, Singh, Raminder, Lippert, Thomas, Attig, Norbert, Janetzko, Florian, Lahiru Gunathilake, Andrew Grimshaw, Memon, Mohammad Shahbaz, Shahbaz Memon   +21 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Morphological and geological features of Drake Passage, Antarctica, from a new digital bathymetric model

Journal of Maps, 2019
The Drake Passage is an oceanic gateway of about 850 km width located between South America and the Antarctic Peninsula that connects the southeastern Pacific Ocean with the southwestern Atlantic Ocean.
F. Bohoyo, R. D. Larter, J. Galindo-Zaldívar, P. T. Leat, A. Maldonado, A. J. Tate, M. M. Flexas, E. J. M. Gowland, J. E. Arndt, B. Dorschel, Y. D. Kim, J. K. Hong, J. López-Martínez, A. Maestro, O. Bermúdez, F. O. Nitsche, R. A. Livermore, T. R. Riley   +17 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Regional characteristics of extreme precipitation events over Aotearoa New Zealand

Weather and Climate Extremes
We document 1394 extreme precipitation events (EPEs) over Aotearoa New Zealand’s (ANZ) Regional Councils between March 1996 and December 2021. The characteristics of EPEs are documented using a novel spatio-temporal framework that diagnoses the peak ...
Gokul Vishwanathan, Adrian J. McDonald, Chris Noble, Dáithí A. Stone, Suzanne Rosier, Alex Schuddeboom, Peter Kreft, Gregor Macara, Trevor Carey-Smith, Greg Bodeker   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source