Results 101 to 110 of about 8,060,325 (282)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Defending the scientific integrity of conservation-policy processes

, 2017
Government agencies faced with politically controversial decisions often discount or ignore scientific information, whether from agency staff or nongovernmental scientists.
Kerr, Jeremy T., Brett Hartl, Jeremy T. Kerr, Martine Maron, Ritchie, Euan G., Maron, Martine, Kingsford, Richard T., Hartl, Brett, Watson, James E. M., Carlos Carroll, Carroll, Carlos, Treves, Adrian, Richard T. Kingsford, Katherine E. Gibbs, Daniel J. Rohlf, Rohlf, Daniel J., Adrian Treves, Euan G. Ritchie, Gibbs, Katherine E., James E. M. Watson, Gretchen T. Goldman, Goldman, Gretchen T.   +21 more
core   +1 more source

“Emergency” multidisciplinary team meeting in cancer: a first feedback from a care team

Journal of Translational Medicine, 2023
Henri-Corto Stoeklé, David Billard, Jaafar Bennouna, Philippe Beuzeboc, Christian Hervé   +4 more
doaj   +1 more source

Back to the roots: reimagining scientific evaluation of research without peer review

Insights: The UKSG Journal
The peer review system, once a noble aspiration, now lags behind the accelerating demands of modern science. This opinion piece calls for a decisive departure from that peer review system and advocates for a return to a more accountable, editorially ...
Malik Sallam
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

New Beginning for Tellus – An Earth System Science Journal by Scientists for Scientists

Tellus: Series A, Dynamic Meteorology and Oceanography
Tellus, originally founded in the late 1940s by Carl-Gustaf Rossby, is relaunched as a community-driven Earth system science journal managed by research-active scientists.
Ilona Riipinen, Stefano Manzoni, Rodrigo Caballero, James Famiglietti, Fabien Roquet, Carlos Sierra, Bjorn Stevens, Trude Storelvmo, Giulia Vico   +8 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

CDC guidance on scientific integrity. Version 2.0 [PDF]

Purpose: The Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (CDC/ATSDR-henceforth referred to as CDC) has numerous policies on various aspects of scientific integrity that may not be known to its scientists ...

core  

Practices and voices shaping research ethics and scientific integrity in translational research in Colombia

Journal of Clinical and Translational Science
Introduction: Due to its rapid expansion, translational research has become a strategic priority in biomedical studies, while simultaneously introducing complex ethical and integrity-related challenges that extend beyond traditional bioethical frameworks.
Manuel Latorre Quintana, Natalia Bolaños-Cristancho, Manuela Fernández Pinto   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source