Results 101 to 110 of about 606,604 (206)

Scientific integrity, misconduct in science

open access: yesSwiss Medical Weekly, 2010
E Bossi
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

Guidelines for Scientific Integrity</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Revista da Escola de Enfermagem da USP</i>, 2004 </span><br><span class="r_sub"><i>Semiramis Melani Melo Rocha<span id="ma_8" style="display:none">, Márcia Niituma Ogata</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+1 more</a></small></i></span><br><small><a href="https://doaj.org/article/653e59a2deb244ebaf0445d6d95085cd" target="_blank" rel="nofollow" title="doaj.org/article/653e59a2deb244ebaf0445d6d95085cd">doaj</a> </small>   <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1590%2FS0080-62342004000400014" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1590/S0080-62342004000400014'); alert('Copied the doi');">copy doi</a> <small>(10.1590/S0080-62342004000400014)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/jcph.70146" target="_blank" rel="nofollow">The Importance of the Peer Review Process to Safeguard Scientific Integrity.</a> <b><a href="https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC13501183&blobtype=pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>J Clin Pharmacol</i></span><br><span class="r_sub"><i>Moore KT.</i></span><br><small><a href="https://europepmc.org/article/MED/41405016#free-full-text" target="_blank" rel="nofollow" title="europepmc.org/article/MED/41405016#free-full-text">europepmc</a> </small>   <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Fjcph.70146" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/jcph.70146'); alert('Copied the doi');">copy doi</a> <small>(10.1002/jcph.70146)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70311" target="_blank" rel="nofollow">In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,</span><br><span class="r_sub"><i>James Britton<span id="ma_10" style="display:none">, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+6 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70311?mi=2or9o2m&af=R&AllField=scientific integrity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70311?mi=2or9o2m&af=R&AllField=scientific integrity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70311" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70311'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70311)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-open_science/" class="suggestion"onclick="show_loader();"><b>open science</b></a><br/><a href="/q-robert_k._merton/" class="suggestion"onclick="show_loader();"><b>robert k. merton</b></a><br/><a href="/q-covid_19/" class="suggestion"onclick="show_loader();"><b>covid 19</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-research_values/" class="suggestion"onclick="show_loader();"><b>research values</b></a><br/><a href="/q-research_assessment/" class="suggestion"onclick="show_loader();"><b>research assessment</b></a><br/><a href="/q-ethics/" class="suggestion"onclick="show_loader();"><b>ethics</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-medicine/" class="suggestion"onclick="show_loader();"><b>medicine</b></a><br/><a href="/q-public_aspects_of_medicine/" class="suggestion"onclick="show_loader();"><b>public aspects of medicine</b></a><br/><a href="/q-bioethics/" class="suggestion"onclick="show_loader();"><b>bioethics</b></a><br/></div></div></div><div class="pagenav"><a href="/q-scientific_integrity/p-10/" rel="nofollow"><b>previous</b></a>   <a href="/q-scientific_integrity/p-9/" rel="nofollow">9</a>  <a href="/q-scientific_integrity/p-10/" rel="nofollow">10</a>  <b>11</b>  <a href="/q-scientific_integrity/p-12/" rel="nofollow">12</a>  <a href="/q-scientific_integrity/p-13/" rel="nofollow">13</a>   <a href="/q-scientific_integrity/p-12/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> <script> (function(ss,ex){ window.ldfdr=window.ldfdr||function(){(ldfdr._q=ldfdr._q||[]).push([].slice.call(arguments));}; (function(d,s){ fs=d.getElementsByTagName(s)[0]; function ce(src){ var cs=d.createElement(s); cs.src=src; cs.async=1; fs.parentNode.insertBefore(cs,fs); }; ce('https://sc.lfeeder.com/lftracker_v1_'+ss+(ex?'_'+ex:'')+'.js'); })(document,'script'); })('JMvZ8gvrWA9a2pOd'); </script> </body> </html>