Results 121 to 130 of about 8,060,325 (282)
Towards the Non-Mertonian Ethos of a Non-Mertonian Science: Situating the Research Value of Openness
NovationIt is hard to disagree with the thrust of René von Schomberg’s position paper. It is driven by the worry that current conceptions of “open science” are all too impoverished – that they need to be complemented by the social practice of “mutual ...
Alfred Nordmann
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Scientific Integrity Under Threat: The Role of the IDSA, PIDS, and SHEA Journals in an Evolving Political Landscape [PDF]
Infect Control Hosp Epidemioleuropepmc +6 more sources
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Editorial: Be positive about the negative in pharmacology: Neuropharmacology 2022
Frontiers in Pharmacology, 2023 Adrian Preda, Rene Oliveira Beleboni
doaj +1 more source
United States Department of Homeland Security Scientific Integrity Policy [PDF]
United States Department of Homeland Security Scientific Integrity ...
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The Executive Order “Restoring Gold Standard Science” is Dangerous for America
AGU AdvancesThe recent U.S. executive order “Restoring Gold Standard Science” poses a significant threat to the U.S. national economy and security. The order replaces the scientific experts who lead U.S.
M. E. Wysession +19 more
doaj +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
United States National Science Foundation (NSF) Scientific Integrity Policy [PDF]
United States National Science Foundation (NSF) Scientific Integrity ...
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FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source