Results 81 to 90 of about 1,497,668 (296)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Current Directions of Entrepreneurship Research in Social Psychology: a Map of the Scientific Landscape

Вестник Московского университета. Серия 14: Психология
Background. Currently, the number of entrepreneurs who want to run a traditional business or a startup is growing rapidly. In scientific circles, there is also increasing interest in the phenomenon of entrepreneurship and, in particular, in the ...
Maria A. Cheremenskaia
doaj   +1 more source

Scientific mapping of environmental, social, and governance (ESG) research from the perspective of stakeholders: A content analysis study [PDF]

Journal of Entrepreneurship, Management and Innovation
PURPOSE: The purpose of this study is to illustrate the thematic evolution and intellectual structure of environmental, social, and governance (ESG) research from the perspective of stakeholders through the scientific mapping of 262 articles published ...
Joanna Błach, Iwona Gorzeń-Mitka, Małgorzata Lipowicz   +2 more
doaj   +1 more source

ARTMAP Neural Networks for Information Fusion and Data Mining: Map Production and Target Recognition Methodologies [PDF]

, 2002
The Sensor Exploitation Group of MIT Lincoln Laboratory incorporated an early version of the ARTMAP neural network as the recognition engine of a hierarchical system for fusion and data mining of registered geospatial images.
Carpenter, Gail, Parsons, Olga
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Analyzing the Intellectual Paradigm and Scientific Mapping of International Researches in the Area of Gamification in Education [PDF]

پژوهش در روش‌های آموزش
In this article, with the aim of better understanding the various topics examined in scientific productions in the area of gamification in education, articles published in prestigious international journals, the extent of scientific collaborations ...
Fatemeh Heidari, Seyed Mohammadbagher Jafari, Seyfollah Fazlollahi Qomshi   +2 more
doaj   +1 more source

Mapping scientific communities at scale

This study introduces a novel methodology for mapping scientific communities at scale, addressing challenges associated with network analysis in large bibliometric datasets. By leveraging enriched publication metadata from the French research portal scanR and applying advanced filtering techniques to prioritize the strongest interactions between ...
Barbier, Victor, Jeangirard, Eric
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Charting the Landscape: Perspectives on Green Innovations in Agriculture

Proceedings
Concern over the impacts of climate change has significantly increased. While these effects are evident across various contexts, this study focuses on how the scientific literature has addressed the role of green innovations in agriculture.
Fernanda Sperotto, Iván Tartaruga
doaj   +1 more source