Results 101 to 110 of about 4,444,969 (268)

Revenue Management and Demand Fulfillment: Matching Applications, Models, and Software [PDF]

Recent years have seen great successes of revenue management, notably in the airline, hotel, and car rental business. Currently, an increasing number of industries, including manufacturers and retailers, are exploring ways to adopt similar concepts ...
Fleischmann, M., Meyr, H., Quante, R.
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

El papel de los modelos en la práctica científica

Revista Científica, 2012
Two decades of discussion about models as a basis for research and scienti- fic knowledge’s advances have allowed to open a new way in an space, which was in darkness due to prevail of theories in its important approximations during XX century. According
ROSA NIDIA TUAY
doaj  

PROTAC-mediated degradation of Bcl-xL potentiates target therapy in preclinical melanoma models

Journal of Experimental & Clinical Cancer Research
Background Bcl-xL plays an important role in tumors from different origins, including melanoma, and for this reason it has been widely targeted with small-molecule BH3 mimetics, which unfortunately show several adverse effects.
Elisabetta Valentini, Giulia Gentile, Marta Di Martile, Simona D’Aguanno, Matteo Brignone, Adriana Maria Di Stefano, Marica Di Caprio, Elisa Melucci, Claudio Botti, Fabio Pelle, Arianna Ortolano, Luigi Fattore, Rita Mancini, Gennaro Ciliberto, Dante Rotili, Donatella Del Bufalo   +15 more
doaj   +1 more source

PURE PROCESS REALISM: THE UNIFICATION OF REALISM AND EMPIRICISM

Manuscrito
I describe the key features of pure process realism-realism about the processes that are identified by experimental dynamics structured by scientific models-showing that the view meets criteria for scientific realism.
WILLIAN PENN
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Linguistically Grounded Models of Language Change

, 2006
Questions related to the evolution of language have recently known an impressive increase of interest (Briscoe, 2002). This short paper aims at questioning the scientific status of these models and their relations to attested data.
Poibeau, Thierry
core   +3 more sources

Modelling scientific publishing

, 2004
Bo-Christer Bjork and Turid Hedlund, A formalised model of the scientific publication process, Online Information Review 28, 8-21 (2004). An open access postprint is available.
openaire   +1 more source