Results 161 to 170 of about 1,654,559 (261)

Models in science

Erasmus Journal for Philosophy and Economics, 2010
Rogier De Langhe
doaj   +1 more source

Complementary roles of virtual and real trials in medicine: An interplay of virtuous spirals. [PDF]

PNAS Nexus
Samei E, Vancoillie L, Wilde M, Frangi AF, Abadi E, Bakic PR, Bliznakova K, Bosmans H, Carton AK, Darambara DG, Kinahan P, Lashgari M, Tanaka R, Wang H, Zakeri A.   +14 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Evidence in the Age of Algorithms: Redefining Emergency Medicine Research. [PDF]

Open Access Emerg Med
Baez AA.
europepmc   +1 more source

Models of Human Scientific Discovery. [PDF]

, 2018
Goldstone, Robert L, Gopnik, Allison, Thagard, Paul, Ulman, Tomer D   +3 more
openaire   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Commentary on the fundamentals and development of artificial intelligence models in the life sciences and best research practices. [PDF]

J Comput Aided Mol Des
Bajorath J.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source