Results 41 to 50 of about 1,654,559 (261)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
AN ECONOMIC MODEL OF SCIENTIFIC RULES [PDF]
Economics and Philosophy, 2006 Empirical reports on scientific competition show that scientists can be depicted as self-interested, strategically behaving agents. Nevertheless, we argue that recognition-seeking scientists will have an interest in establishing methodological norms which tend to select theories of a high epistemic value, and that these norms will be still more ...
Ferreira, José Luis +1 more
openaire +2 more sources
Testing Causality in Scientific Modelling Software
ACM Transactions on Software Engineering and Methodology, 2023 From simulating galaxy formation to viral transmission in a pandemic, scientific models play a pivotal role in developing scientific theories and supporting government policy decisions that affect us all. Given these critical applications, a poor modelling assumption or bug could have far-reaching consequences.
Andrew G. Clark +6 more
openaire +5 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Fen ve Matematik Öğretmen Adaylarının Modellerin Bilim ve Fendeki Rolüne ve Amacına İlişkin Algıları
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2009 Bilimsel süreçlerin ve bilimsel okuryazarlığın ayrılmaz birer parçasıolan modeller, betimledikleri sistemin basitleştirilmiştemsilleridir ve nesneleri, olayları, fikirleri ya da soyut kavramlarıalgılanır kılan araçlardır.
Nilüfer Cerit Berber, Hatice Güzel
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Modeling and Storing Scientific Protocols [PDF]
, 2006 We propose an abstract model for scientific protocols, where several atomic operators are proposed for protocol composition We distinguish two different layers associated with scientific protocols: design and implementation, and discuss the mapping between them We illustrate our approach with a representative example and describe ProtocolDB, a ...
Natalia Kwasnikowska +2 more
openaire +1 more source