Results 91 to 100 of about 1,135,884 (299)

Introduction; Representation in Scientific Practice Revisited

open access: yes, 2013
   A new series of essays that sets the bar for the study of representation in science in the twenty-first century. Chapters span a range of topics, including molecular modelling, nano-imaging, mathematical formalisms, and digital imagery in neuroscience,
Vertesi, Janet,   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Factors related to out-of-hours help-seeking for acute health problems: a survey study using case scenarios

open access: yesBMC Public Health, 2019
Background The acute out-of-hours healthcare services are challenged by increasing demand in many countries. We aimed to examine factors influencing the intended help-seeking in out-of-hours care for acute health problems during evenings, nights, and ...
Ellen Keizer   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Practice Questions - Scientific Notation

open access: yes, 2010
A ten question multiple choice test on Scientific Nottaion.
J. Koenig
core  

Dis(en)abled: legitimating discriminatory practice in the name of inclusion? [PDF]

open access: yes, 2016
This article explores tensions between the policies and practice of inclusion and the lived experiences of disabled young people in education. Drawing on the narratives of two young men who participated in a small pilot study, it utilises theoretical ...
Atkins, Liz, Liz Atkins, Atkins, L.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

In Silico Medicine: The Practitioners’ Points of View Medicine: The Practitioners’ Points of View Medicine:

open access: yesHumana.Mente: Journal of Philosophical Studies, 2016
In this article, which is assembled from interviews, the main issues of in silico medicine, present and future, are discussed by three scientists who are directly involved in the implementation and development of in silico techniques.
Matteo Cerri   +2 more
doaj  

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