Results 71 to 80 of about 958,595 (253)

Patient-perceived barriers and facilitators to the implementation of a medication review in primary care: a qualitative thematic analysis

BMC Family Practice, 2018
Background Although polypharmacy can cause adverse health outcomes, patients often know little about their medication. A regularly conducted medication review (MR) can help provide an overview of a patient’s medication, and benefit patients by enhancing ...
Mirella Carolin Uhl, Christiane Muth, Ferdinand Michael Gerlach, Goentje-Gesine Schoch, Beate Sigrid Müller   +4 more
doaj   +1 more source

Statistical significance and its critics: practicing damaging science, or damaging scientific practice? [PDF]

Synthese, 2022
Mayo DG, Hand D.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Controlled-Release Oxycodone and Naloxone in the Treatment of Chronic Low Back Pain: A Placebo-Controlled, Randomized Study

Pain Research and Management, 2013
BACKGROUND: For Canadian regulatory purposes, an analgesic study was required to complement previously completed, pivotal studies on bowel effects and analgesia associated with controlled-release (CR) oxycodone/CR naloxone.
C Cloutier, J Taliano, W O’Mahony, M Csanadi, G Cohen, I Sutton, D Sinclair, M Awde, S Henein, L Robinson, J Eisenhoffer, PS Piraino, Z Harsanyi, KJ Michalko   +13 more
doaj   +1 more source

Good Scientific Practice and Ethics in Sports and Exercise Science: A Brief and Comprehensive Hands-on Appraisal for Sports Research. [PDF]

Sports (Basel), 2023
Arora NK, Roehrken G, Crumbach S, Phatak A, Labott BK, Nicklas A, Wicker P, Donath L.   +7 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

In Silico Medicine: The Practitioners’ Points of View Medicine: The Practitioners’ Points of View Medicine:

Humana.Mente: Journal of Philosophical Studies, 2016
In this article, which is assembled from interviews, the main issues of in silico medicine, present and future, are discussed by three scientists who are directly involved in the implementation and development of in silico techniques.
Matteo Cerri, Markus Reiterer, Marco Viceconti   +2 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Multicenter Cohort Study of 3805 RibXcar Cases: Safety and Efficacy in Incisionless Rib Remodeling

Plastic and Reconstructive Surgery, Global Open
Background:. Minimally invasive ultrasound-guided rib remodeling using percutaneous punctures (RibXcar) is a technique designed to modify thoracic contour and reduce waist circumference.
Raúl M. Manzaneda Cipriani, MD, Héctor Duran, MD, Gerardo A. Adrianzen, MD, Emmanuel Flores, MD, Hassan Ben Moussa, MD, Alexis Delobaux, MD, Zamir Paez, MD, Jose David Salazar, MD, David A. Sieber, MD   +8 more
doaj   +1 more source

Teaching: confidence, prediction and tolerance intervals in scientific practice: a tutorial on binary variables. [PDF]

Emerg Themes Epidemiol, 2021
Hartnack S, Roos M.
europepmc   +1 more source