Results 71 to 80 of about 1,135,884 (299)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
BRIDGING A SUPPOSEDLY UNBRIDGEABLE GAP: ELABORATING SCIENTIFIC KNOWLEDGE FROM AND FOR PRACTICE [PDF]
This article aims at advancing the still on-going conversations about the so-called research/practice gap. Some academics argue that it is not possible to develop knowledge that is both academically valuable and helpful for practice, while others hold ...
M.-J. Avenier, J. Bartunek
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Do guidelines create uniformity in medical practice? [PDF]
, 2010 This article aimed to test the general hypothesis that guidelines create uniformity, or reduce variation, in medical practice. Medical practice variation has policy interest and is one of the reasons for developing guidelines.
de Jong, J.D. +12 more
core +1 more source
An interview with Kenneth Aizawa
The ReasonerHykel Hosni interviews Kenneth Aizawa, Professor of Philosophy of Science at Rutgers University, Newark. The interview opens with Aizawa’s reflections on the challenges currently confronting U.S. universities under the second Trump administration.
Hykel Hosni
doaj +1 more source
Guiding Students’ Scientific Practice
SAGE Open, 2014 Many science education programs involve scientists in K-12 education to support students’ engagement in scientific practices and learning science process skills and scientific epistemologies.
Deniz Peker, Erin L. Dolan
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Teachers’ experiences of teaching ‘ideas-about-science’ and socio-scientific issues
, 2007 Teaching of socio-scientific issues encourages a focus on ‘ideas-about-science’ (the processes and practices of science) and consideration of scientific evidence and values.
Hanley, Pam +2 more
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HOBBES AND SCIENTIFIC PRACTICE IN THE LEVIATHAN
International Journal of Research -GRANTHAALAYAH, 2018 Hobbes in the seventeenth century (1639 - 1668), we must emphasize that suggests that taste or infatuation for science bodies (physical), because as he reminds us at the end of the leviathan in 1651; you are happy to return to their initial speculations about (De Corpore) natural bodies. (Hobbes Leviatã, 2003, p. 22).
openaire +3 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Practice-oriented controversies and borrowed epistemic support in current evolutionary biology: phylogeography as a case study. [PDF]
, 2011 Although there is increasing recognition that theory and practice in science are often inseparably intertwined, discussions of scientific controversies often continue to focus on theory, and not practice or methodologies.
Olson, Mark E. +2 more
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