Results 51 to 60 of about 958,595 (253)

Use of office spirometers in Flemish general practice: results of a telephone survey

Monaldi Archives for Chest Disease, 2016
Background. While office spirometry is seen as potentially useful and feasible in general practice, little is known about its use in Flemish general practice.
N. Boffin, V. Van der Stighelen, D. Paulus, P. Van Royen   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Problem of Demarcation: Essentialist and Constructivist Perspectives

Profil
This paper examines the problem of demarcation in contemporary philosophy of science, with particular emphasis on the transition from essentialist to constructivist approaches.
Mariana Szapuová
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

HOBBES AND SCIENTIFIC PRACTICE IN THE LEVIATHAN

International Journal of Research -GRANTHAALAYAH, 2018
Hobbes in the seventeenth century (1639 - 1668), we must emphasize that suggests that taste or infatuation for science bodies (physical), because as he reminds us at the end of the leviathan in 1651; you are happy to return to their initial speculations about (De Corpore) natural bodies. (Hobbes Leviatã, 2003, p. 22).
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An interview with Kenneth Aizawa

The Reasoner
Hykel Hosni interviews Kenneth Aizawa, Professor of Philosophy of Science at Rutgers University, Newark. The interview opens with Aizawa’s reflections on the challenges currently confronting U.S. universities under the second Trump administration.
Hykel Hosni
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Construction and practical implications of an interdisciplinary teaching path for DNA diffraction patterns—from the perspective of scientific history and principle visualization

Cogent Education
DNA diffraction patterns are critical evidence for the DNA double helix and an interdisciplinary bridge linking biology, chemistry and physics. To address gaps in high school biology teaching including ambiguous pattern-structure reasoning and fragmented
Dingcheng Luo, Dingguo Zhang, Chang Sun, Wenrui Xie, Dange Gao, Jingyao Qu, Benjie Zhang, Shatar Zuya, Liping Xu   +8 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source