Results 41 to 50 of about 10,831,688 (294)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Progress in the field of iodine deficiency disorders prevention in Republic of Uzbekistan (1998–2016)

Клиническая и экспериментальная тиреоидология, 2017
In spite of the works performed against IDD, it still remains severe in Uzbekistan. Progress to lower iodine deficiency was due to the activities to liquidation of iodine deficiency disorders (IDD) including supply with iodizing equipment and ...
Said I. Ismailov, Murodjon M. Rashitov
doaj   +1 more source

Best Practices for Scientific Computing

PLoS Biology, 2014
Scientists spend an increasing amount of time building and using software. However, most scientists are never taught how to do this efficiently. As a result, many are unaware of tools and practices that would allow them to write more reliable and maintainable code with less effort. We describe a set of best practices for scientific software development
Wilson, G, Aruliah, DA, Brown, CT, Hong, NPC, Davis, M, Guy, RT, Haddock, SHD, Huff, KD, Mitchell, IM, Plumbley, MD, Waugh, B, White, EP, Wilson, P   +12 more
openaire   +10 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Scientific Justification of Cryonics Practice [PDF]

Rejuvenation Research, 2008
Very low temperatures create conditions that can preserve tissue for centuries, possibly including the neurological basis of the human mind. Through a process called vitrification, brain tissue can be cooled to cryogenic temperatures without ice formation.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Examining the Challenges of Scientific Workflows

, 2007
Workflows have recently emerged as a paradigm for representing and managing complex distributed scientific computations and therefore accelerate the pace of scientific progress.
Gannon, Dennis, Fox, Geoffrey, Myers, Jim, Ellisman, Mark, Gil, Yolanda, Deelman, Ewa, Fahringer, Thomas, Goble, Carole, Livny, Miron, Moreau, Luc   +9 more
core   +2 more sources

Three-dimensional assessment of the relative position of the roots of the teeth in the anterior lower jaw for treatment planning for class III occlusion anomalies using mini-implants

Эндодонтия Today, 2020
Relevance. The use of skeletal support in orthodontics led to the use of elastic traction and mini-implants for upper jaw traction in class III treatment, however, when planning the placement, clinicians did not take into account the anatomical ...
V. A. Mazhnikova, A. A. Abramyan, M. M. Shubitidze, Sh. M. Solimanov, A. O. Kuznetsova, R. V. Volberg   +5 more
doaj   +1 more source