Results 81 to 90 of about 958,595 (253)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The hidden side of animal cognition research: Scientists' attitudes toward bias, replicability and scientific practice. [PDF]

PLoS One, 2021
Farrar BG, Ostojić L, Clayton NS.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

RibXcar with Dots Point Technique: The Science of Fracture as a Safety Principle

Plastic and Reconstructive Surgery, Global Open
Background:. Minimally invasive percutaneous aesthetic rib reshaping (RibXcar) aims to reduce waist circumference through rib angulation produced by controlled monocortical fractures.
Raúl M. Manzaneda Cipriani, MD, Héctor Duran, MD, Gerardo A. Adrianzen, MD, Emmanuel Flores, MD, Enrique Romero Algara, MD, Jose David Salazar, MD, Hassan Ben Moussa, MD, Boris Fogel, MD, Richard Chumbiauca Munares, MD, Gustavo Enrique Gamarra Quispe, MD   +9 more
doaj   +1 more source

Supporting Scientific Practice through Model-Based Inquiry: A Students'-Eye View of Grappling with Data, Uncertainty, and Community in a Laboratory Experience. [PDF]

CBE Life Sci Educ, 2021
Bolger MS, Osness JB, Gouvea JS, Cooper AC.   +3 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Fear of missing out (FoMO) in the digital age: implications for academic productivity and sleep quality among Saudi university students

Frontiers in Psychology
BackgroundFear of missing out (FoMO) has emerged as an important psychological concern among university students, associated with excessive social media engagement and linked to academic and sleep-related outcomes.
Fahad Alzahrani, Raid Raidan, Wejdan Al Harbi, Sadeem S. Aljutily, Leen Almuzainy, Jood Aljohani, Enas Aljohani, Majed Alrefaei, Salman Aljohani, Yousef Alorfi, Sultan S. Al Thaqfan, Saad B. Fallatah, Sultan Othman Alolayan, Ehsan Habeeb, Faris S. Alnezary   +14 more
doaj   +1 more source

Correction to: Medical Students' Acquaintance with Core Concepts, Institutions and Guidelines on Good Scientific Practice: A Pre- and Post-questionnaire Survey. [PDF]

Sci Eng Ethics, 2021
Fuerholzer K, Schochow M, Peter R, Steger F.   +3 more
europepmc   +1 more source