Results 81 to 90 of about 1,135,884 (299)

Controlled-Release Oxycodone and Naloxone in the Treatment of Chronic Low Back Pain: A Placebo-Controlled, Randomized Study

Pain Research and Management, 2013
BACKGROUND: For Canadian regulatory purposes, an analgesic study was required to complement previously completed, pivotal studies on bowel effects and analgesia associated with controlled-release (CR) oxycodone/CR naloxone.
C Cloutier, J Taliano, W O’Mahony, M Csanadi, G Cohen, I Sutton, D Sinclair, M Awde, S Henein, L Robinson, J Eisenhoffer, PS Piraino, Z Harsanyi, KJ Michalko   +13 more
doaj   +1 more source

Patient-perceived barriers and facilitators to the implementation of a medication review in primary care: a qualitative thematic analysis

BMC Family Practice, 2018
Background Although polypharmacy can cause adverse health outcomes, patients often know little about their medication. A regularly conducted medication review (MR) can help provide an overview of a patient’s medication, and benefit patients by enhancing ...
Mirella Carolin Uhl, Christiane Muth, Ferdinand Michael Gerlach, Goentje-Gesine Schoch, Beate Sigrid Müller   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Orienteering Tools: Biomedical Research with Ontologies

Humana.Mente: Journal of Philosophical Studies, 2016
Biomedical ontologies are considered a serious innovation for biomedical research and clinical practice. They promise to integrate information coming from different biological databases thus creating a common ground for the representation of knowledge in
Federico Boem
doaj  

Safety and Effectiveness of Real-time Direct Vision Liposuction Performed Using Intraoperative Ultrasonography

Plastic and Reconstructive Surgery, Global Open
Background:. Liposuction is a frequently performed procedure for body contouring. Various advances, such as retraction technology and ultrasonography, have helped achieve better results, verify the correct anatomical level, and increase the safety of the
Raúl Martín Manzaneda Cipriani, MD, Hector Duran, MD, Gerardo Adrianzen, MD, Luis Carvalho, MD, Mauricio Viaro, MD, Emmanuel Flores, MD, Alexis Delobaux, MD, Ricardo Babaitis, MD, Hassan Ben Moussa, MD, Jack Liu, MD   +9 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Using theory to inform capacity-building: Bootstrapping communities of practice in computer science education research [PDF]

, 2006
In this paper, we describe our efforts in the deliberate creation of a community of practice of researchers in computer science education (CSEd). We understand community of practice in the sense in which Wenger describes it, whereby the community is ...
Fincher, Sally, Tenenberg, Josh
core   +1 more source

Burden of allergic rhinitis in the United Kingdom

Frontiers in Allergy
IntroductionAllergic rhinitis (AR) is a systemic respiratory condition that is associated with a considerable humanistic burden and is frequently underdiagnosed.
Michael Jones, Hilary Shepherd, Diane Hatziioanou, Daphne Martin, Chisomo Mutafya, Ulf Bohman, Susan Hodgson, Rachael Williams   +7 more
doaj   +1 more source

Understanding Musical Consonance and Dissonance: Epistemological Considerations from a Systemic Perspective

Systems, 2014
Different accounts have been given in order to face the problem of the emergence of musical consonance and dissonance. Getting a more adequate comprehension of such phenomenology may require a systemic view to integrate such multidimensionality into a ...
Nicola Di Stefano, Marta Bertolaso
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source