Results 121 to 130 of about 1,135,884 (299)

Genetic Predisposition to Prediabetes in the Kazakh Population

Current Issues in Molecular Biology
The aim of this study was to conduct a comparative analysis of the population frequencies of the minor allele of polymorphic variants in the genes TCF7L2 (rs7903146) and PPARG (rs1801282), based on the genome-wide association studies analysis data ...
Gulnara Svyatova, Galina Berezina, Alexandra Murtazaliyeva, Altay Dyussupov, Tatyana Belyayeva, Raida Faizova, Azhar Dyussupova   +6 more
doaj   +1 more source

Correction to: Medical Students' Acquaintance with Core Concepts, Institutions and Guidelines on Good Scientific Practice: A Pre- and Post-questionnaire Survey. [PDF]

Sci Eng Ethics, 2021
Fuerholzer K, Schochow M, Peter R, Steger F.   +3 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Changeableness of the surgical practice and the steadiness of the surgical scientific work

, 1990
Kirurška praksa je podložna stalnoj promjeni, kako bi se pronašlo bolje, sigurnije i efikasnije izlječenje. Nasuprot tome, metode znanstvenog istraživanja u kirurgiji osnovane na ideji »rerum cognoscere causas« ostaju nepromijenjenima.
Štulhofer, Mladen, Mladen Štulhofer
core  

The Scientific Practice of Assessing Progress [PDF]

, 2011
In a recent debate about the nature of scientific progress, Alexander Bird and Darrell Rowbottom have argued for two competing accounts of progress. According to Bird, scientific progress consists in the accumulation of scientific knowledge.
Mizrahi, Moti
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The myExperiment Open Repository for Scientific Workflows

myExperiment is an open repository solution for the born-digital items arising in contemporary research practice, in particular scientific workflows and experiment plans. Launched in November 2007, the public repository (myexperiment.org) has established
De Roure, David, Aleksejevs, Sergejs, Michaelides, Danius, Cruickshank, Don, Bhagat, Jiten, Newman, David, Goble, Carole, Bechhofer, Sean   +7 more
core  

Report on the Second Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE2)

, 2016
This technical report records and discusses the Second Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE2). The report includes a description of the alternative, experimental submission and review process, two workshop ...
Wilkins-Diehr, Nancy, Richard Littauer, Neil Chue Hong, Nancy Wilkins-Diehr, Karen A. Cranston, James Howison, Clune, Thomas L., Cranston, Karen A., Littauer, Richard, Frank Seinstra, Matthew Jones, de Val-Borro, Miguel, Thomas L. Clune, Venters, Colin, Seinstra, Frank, Hong, Neil Chue, Jones, Matthew, Daniel S. Katz, Sou-Cheng T. Choi, Katz, Daniel S., Choi, Sou-Cheng T., Howison, James, Colin C. Venters, Miguel de Val-Borro   +23 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Metaphysics of Scientific Practice

The method of metaphysics of scientific practice consists in developing metaphysical claims on the basis of empirical information from and about scientific practice. This method stands in the tradition of naturalistic or scientific metaphysics on the one
Suárez, Javier, Kaiser, Marie I.
core   +2 more sources