Results 141 to 150 of about 1,135,884 (299)

Forging Forward Together: Transforming Scientific Practice to Accelerate Scientific Progress. [PDF]

Ann Behav Med, 2020
Hall KL.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Scientific personas in theory and practice : Ways of creating scientific, scholarly, and artistic identities

, 2018
The concept of scientific persona was developed by historians of science at the Max Planck Institute in Berlin fifteen years ago in order to understand how science works and how it can be conducted in a credible way. The Latin word persona means mask and
Bosch, Mineke, Wils, Kaat, Niskanen, Kirsti,   +2 more
core  

Re-presenting herbal medicine as phytotherapy: a strategy of professionalisation through the formation of a 'scientific' medicine [PDF]

, 2002
Previous research into complementary and alternative medicine has failed to accord each form of alternative medical intervention individual significance.
VanMarie, Edmund
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Identity of Organisms in Scientific Practice: Integrating Historical and Relational Conceptions. [PDF]

Front Physiol, 2020
Montévil M, Mossio M.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Do We Need a Scientific Revolution?

, 2008
Many see modern science as having serious defects, intellectual, social, moral. Few see this as having anything to do with the philosophy of science.
Maxwell, Nicholas, Maxwell, N
core  

Characteristics and Utilization Patterns of Medicare Beneficiaries Initiating Long-Acting Injectable Antipsychotic Medications

ClinicoEconomics and Outcomes Research
Michael Grabner,1 Yueh-Yi Chiang,2 Chia-Chen Teng,1 Susan dosReis,2 Katherine M Harris1 1Carelon Research, Wilmington, DE, USA; 2Department of Practice, Sciences, and Health Outcomes Research, University of Maryland School of Pharmacy, Baltimore, MD ...
Grabner M, Chiang YY, Teng CC, dosReis S, Harris KM   +4 more
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