Results 131 to 140 of about 1,135,884 (299)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
A Minimal Metaphysics for Scientific Practice
, 2021 What are the metaphysical commitments which best 'make sense' of our scientific practice (rather than our scientific theories)? In this book, Andreas Hüttemann provides a minimal metaphysics for scientific practice, i.e.
Hüttemann, Andreas
core
Increasing the Reproducibility of Science through Close Cooperation and Forking Path Analysis
Frontiers in Psychology, 2017 Jan Wacker
doaj +1 more source
[Situational judgement test as teaching method for the critical discussion on scientific practice and misconduct]. [PDF]
Wien Med Wochenschr, 2021 Klemmt C, König S.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Semantic type checking in scientific workflows
, 2009 Scientists are increasingly utilizing Grids to manage large data sets and execute scientific experiments on distributed resources [1]. Scientific workflows are used as means for modelling and enacting scientific experiments [2].
Derouiche, Kheiredine
core
Quality aspects of Dutch general practice-based data: a conceptual approach.
, 2013 Background: General practice–based data, collected within general practice registration networks (GPRNs), are widely used in research. The quality of the data is important but the recording criteria about what type of information is collected and how ...
Dungen, C. van den +6 more
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