Results 121 to 130 of about 11,703,274 (378)

The relationship between environmental factors and migration processes in Kyrgyzstan [PDF]

E3S Web of Conferences
This article examines the influence of environmental factors on migration processes in Kyrgyzstan, taking into account their socio-economic and political aspects.
Nuraliev Nurlan Akimbekovich, Myrzabayeva Nargiza Myrzabekovna, Zhoomartova Eliza Zhoomartovna   +2 more
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Dynamics of feed water flow rate control system with low- noise regulator

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017
We present the results of modeling a feed water control system. The system contains two regulatory devices the feed valve to control the flow rate, with electrohydraulic control, and the throttle valve to maintain constant pressure differential on the ...
E. G. Berestovitskiy, P. I. Kizilov, A. N. Kruchkov, N. V. Pialov   +3 more
doaj   +1 more source

Quantity v/s quality of scientific publications: an analysis for main cities of Spain (2001-2007) [PDF]

Since the last quarter of the 20th century, most of the world population has experimented an important process of globalization, mainly due to; the accelerated knowledge production, the increase of intangible capital on a macroeconomic scale, the ...
Carlos Marmolejo Duarte, Claudia Pérez Prieto   +1 more
core  

Organic Fodder Production in Intensive Organic Livestock Production in Europe: Recent Scientific Findings and the Impact on the Development of Organic Farming [PDF]

, 2005
Organic farming is practiced in over 100 countries on more than 26 million hectares. In the European Union (EU 25), about 5.6 million hectares of farm land are certified under the EU organic farming regulation 2092/91/EEC.
Böhm, Herwart, Rahmann, Gerold
core  

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Validation of the method for determination of prekallikrein activator in Human Albumin

Биопрепараты: Профилактика, диагностика, лечение, 2018
Prekallikrein activator (PKA) is regarded as one of the most important factors determining the safety of blood products such as albumin and intravenous immunoglobulin.
M. V. Tomilin, E. V. Filatova, M. M. Kuznetsova, V. V. Sudakova, N. V. Zubkova   +4 more
doaj  

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Technology geography: a new area of scientific inquiry [PDF]

, 2003
Operations management, international management, public policy and\ud economic geography are four scientific areas, which come together in the study of\ud international technology transfer.
Bruijn, Erik J. de, Steenhuis, Harm-Jan
core   +2 more sources