Results 111 to 120 of about 1,611,826 (291)

Economic and social studies of scientific research: nature and origins [PDF]

Interest in the role that science and scientific research play in economics and the other social sciences has exploded in the last fifty years. This attention undoubtedly reflects the increased importance that scientific research is contributing more and
Mario Coccia
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

MAN-MADE RADIONUCLIDES IN THE NEAR-THE-GROUND ATMOSPHERIC LAYER DUE TO THE FUKUSHIMA ACCIDENT

Радиационная гигиена, 2015
The article presents information about the main observation results of radiometric departments of the Federal Service for Hydrometeorology and Environmental Monitoring for changes in the radiation situation on the territory of Russia following the ...
V. G. Bulgakov, S. M. Vakulovsky, V. M. Kim, O. N. Polyanskaya, A. D. Uvarov, V. N. Yahryushin   +5 more
doaj  

Frequency of Scientific Production in Information Sciences [PDF]

, 2009
The aim of this research is to investigate the development of the Information Sciences in Croatia. The specific research goal was to follow scientific production of the doctoral candidates after completion of their doctoral studies according to ...
Bačić, Emil, Pleše, Tihomir, Tomić, Ivana   +2 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Pharmaco-Technological Characterization, Structural Analysis, and Toxicological Evaluation of the Novel Polyene Antibiotic Roseofungin for Drug Development

Pharmaceutics
Background/Objectives: pentane polyene antibiotic Roseofungin produced by actinomycetes possessing wide range of antimicrobial activity. Methods: The structure of novel polyene antibiotic Roseofungin was confirmed through FTIR, H1 nuclear magnetic ...
Amankeldy Sadanov, Dmitriy Berillo, Assya Bagimbayeva, Gul Baimakhanova, Liliya N. Ibragimova, Iliyas Raikhanovich Kulmaganbetov, Farida Nurmaganbetova, Gulbany Sarsenbaeva, Saltanat Orazymbet, Baiken Baimakhanova, Olga Lakh, Diana Tleubekova, Gulnara T. Dzhakibaeva, Tulegen Mussaldinov   +13 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

TABLETS. REGULATORY REQUIREMENTS OF THE STATE PHARMACOPOEIA XIII EDITION

Разработка и регистрация лекарственных средств, 2019
Comparative analysis of pharmacopoeial requirements for dosage forms tablets has been made due to the introduction of the State Pharmacopoeia of the Russian Federation XIII edition. An overview of changed requirements can be useful for revision (reissue)
N. V. Isaeva, A. I. Tulaykin, E. V. Sheshegova   +2 more
doaj  

Editor's Introduction: Scientific and Technical Human Capital [PDF]

Human capital and social networks are the two pillars supporting scientists' and engineers' ability to contribute knowledge. Throughout their careers, scientists seek to enhance both.
Barry Bozeman, Vincent Mangematin
core  

Scientific Concept for Analyzing the Potential of Energy-Oriented Production Planning and Control in SMEs

495508The energy industry is in a constant state of change: the expansion of renewable energy, fluctuating energy prices, opportunities for self-generation and storage, and different electricity procurement models.
Roth, Stefan, Rischmann, Manuel, Schmidt, Matthias, Demke, Tabea Marie, Weber, Markus, Hiller, Tobias, Nyhuis, Peter   +6 more
core   +1 more source