Results 101 to 110 of about 12,733,834 (284)

Measuring. Monitoring. Management. Control

open access: yesИзмерение, мониторинг, управление, контроль
Background. The use of natural gas as a fuel is becoming increasingly popular, as gas is more environmentally friendly and cheaper than gasoline. To refuel equipment with gas fuel, an automotive gas-filling compressor station is used, where compression ...
V.D. Yezhizhanskiy   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Validation of the method for determination of prekallikrein activator in Human Albumin

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2018
Prekallikrein activator (PKA) is regarded as one of the most important factors determining the safety of blood products such as albumin and intravenous immunoglobulin.
M. V. Tomilin   +4 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Accounting for mechanical stresses in combined dielectrics for VLSI capacitors

open access: yesТехнологія та конструювання в електронній апаратурі, 2003
A variant of a combined capacitor dielectric based on tantalum pentoxide for VLSI capacitors is proposed. To find the optimal combination of layers in which the Si—SiO₂—Ta₂O₅ system does not undergo elastic mechanical deformation, a stress model was ...
V. A. Pilipenko   +2 more
doaj  

Profile and scientific production of Brazilian researchers in dental materials

open access: yes
describe the demographic characteristics and academic production of the National Council for the Development of Science and Technology (CNPq) researchers whose areas of expertise focus on dental materials.
Daniela Araújo Veloso Popoff, Raquel Conceição Ferreira, Daniella Reis B. Martelli, Eduardo Araújo de Oliveira, João Robson Vieira Júnior, Hercílio Martelli-Júnior
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Reference Intervals of Mass Coefficients and Absolute Weights of Mini Pigs’ Organs

open access: yesВетеринарная патология
Introduction. Measurement of weights and calculation of mass coefficients of the laboratory animals’ internal organs are the integral stages of toxicological research. However, the absence of the correct intra-laboratory reference intervals corresponding
E. V. Simonova   +4 more
doaj   +1 more source

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