Results 91 to 100 of about 12,733,834 (284)

Technical Production Showcase 2015 Photo Slideshow

, 2015
A short video containing Photos from the Launch of the Technical Production Showcase ...
QUT Technical Production
core   +1 more source

Bulletin of the scientific laboratories of Denison University.

, 1885
Title varies slightly.Mode of access: Internet.Official organ of: Denison Scientific Association ...
Denison Scientific Association., Denison University.   +1 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The relationship between environmental factors and migration processes in Kyrgyzstan [PDF]

E3S Web of Conferences
This article examines the influence of environmental factors on migration processes in Kyrgyzstan, taking into account their socio-economic and political aspects.
Nuraliev Nurlan Akimbekovich, Myrzabayeva Nargiza Myrzabekovna, Zhoomartova Eliza Zhoomartovna   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Technical Production Showcase 2012 Year In Review

, 2012
Video Package 2012 Technical Production Year In ...
QUT Technical Production
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A brief history of the concept of waste in production [PDF]

Purpose: The concept of waste has been used in relation to production since the beginning of the 20th century. As it is well-known, it is a foundational notion for the Toyota Production System and its derivatives, like lean production.
Koskela, Lauri, Sacks, R., Rooke, John
core   +3 more sources

Co-Cultivation of Komagataeibacter xylinus MS2530 with Various Yeast Strains: Production and characterization of bacterial cellulose Films

Carbohydrate Polymer Technologies and Applications
High production costs and low yield of bacterial cellulose (BC) remain major impediments to the large-scale industrial production of BC. Therefore, the cost reduction through utilization of inexpensive cultivation media, such as recycled industrial waste,
Marina Paronyan, Lusine Saghatelyan, Sona Avetisyan, Haykanush Koloyan, Marina Kinosyan, Valeri Bagiyan, Susanna Hovhannisyan, Olga Akopian, Anichka Hovsepyan   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source