Results 71 to 80 of about 2,357,575 (329)

Making available scientific information in the third millennium: perspectives for the neuroscientific community [PDF]

, 2006
The rules governing the globalised process of sharing scientific information in the research community are rapidly changing. From the 1950s, commercial publishers started owning a large number of scientific journals and consequently the marketable value ...
Alleva, Enrico, Branchi, Igor
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Potential climatic transitions with profound impact on Europe [PDF]

, 2011
We discuss potential transitions of six climatic subsystems with large-scale impact on Europe, sometimes denoted as tipping elements. These are the ice sheets on Greenland and West Antarctica, the Atlantic thermohaline circulation, Arctic sea ice, Alpine
A Born, A Ganachaud, A Ganopolski, A Hu, A Jones, A Laurian, A Levermann, A Levermann, A Levermann, A Levermann, A Schmittner, A Winguth, AA Scaife, Anders Levermann, Andrey Ganopolski, B Dickson, B Schaefli, B Zwierl, BJ Soden, BN Goswami, C Deser, C Haas, C Harris, C Schnadt, C Schoof, C Stick, C Vincent, CAPE-Last Interglaicial Project Members, CL Parkinson, D Farinotti, D Notz, D Pollard, D Stammer, DA Lashof, DA Rothrock, DB Kirk-Davidoff, DG Vaughan, Dirk Notz, DK Perovich, DM Holland, DM Lawrence, DT Shindell, DWJ Thompson, E Kriegler, E Meur Le, E Rignot, E Rignot, E Rignot, EJ Rignot, F Paul, F Paul, G Cogley, G Jouvet, G Kaser, G Manney, G Manney, G Manney, GA Meehl, GJ Oldenborgh van, H Goosse, H Hátún, HD Pritchard, HJ Schellnhuber, I Auer, I Eisenmann, I Joughin, I Joughin, I Velicogna, J Maslanik, J Noetzli, J Oerlemans, J Oerlemans, J Oerlemans, J Ridley, J Ridley, J Stroeve, J Weertman, J Yin, J Yin, J Zhang, JA Church, JC Comiso, JE Kay, JF McManus, JH Jungclaus, JL Bamber, JL Chen, JM Gregory, JM Gregory, Jonathan L. Bamber, JP Wilkinson, JR Miller, JT Overpeck, JX Mitrovica, K Eckhardt, K Zickfeld, KH Rosenlof, Kirstin Krüger, LC Sime, LH Smedsrud, M Beniston, M Dameris, M Hoelzle, M Hofmann, M Honda, M Huss, M Huss, M Huss, M Ogi, M Rex, M Rex, M Scheffer, M Stendel, M Vellinga, M Vellinga, M Wang, M Winton, M Winton, M Zemp, M Zemp, Matthias Huss, MF Meier, MM Holland, Neil R. P. Harris, NP Harris, NW Arnell, O Solomina, P Huybrechts, P Wadhams, P Wadhams, P Wadhams, Peter Wadhams, PM Forster, PU Clark, R Hock, R Lindsay, RE Kopp, RJ Braithwaite, RJ Stouffer, Ronald W. Lindsay, RP Scherer, S Amstrup, S Gruber, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Solomon, S Solomon, S Tegtmeier, S Tietsche, SJ Evans, SJ Oltmans, SL Weber, SL Weber, SS Drijfhout, Susanne Weber, Sybren Drijfhout, T Hattermann, T Kuhlbrodt, T Naish, T Toniazzo, Timothy M. Lenton, TM Lenton, V Petoukhov, VM Kattsov, W Haeberli, W Haeberli, W Weijer, Winfried Haeberli, WJ Randel, WT Pfeffer, Y Wang, ZW Kundzewicz   +174 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Parameterized post-Newtonian limit of Horndeski's gravity theory

, 2015
We present a recent result on the parameterized post-Newtonian (PPN) limit of Horndeski's gravity theory and its consistency with solar system observations.Comment: 2 pages, no figures; to appear in the conference proceedings of the XIIth International
Hohmann, Manuel
core   +1 more source

Elektronik Yayıncılık, Bilimsel İletişim ve Kütüphaneler [PDF]

, 1997
This article deals with the electronic publishing and scientific communication and discusses, from various aspects, the impact of electronic publishing on libraries.
Tonta, Yaşar
core   +2 more sources

Of Publishing Scientific Papers

The American Journal of the Medical Sciences, 1955
Mode of access: Internet.
openaire   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A Contrastive Study of Practical Modes of Data Publishing——Take the Field of Earth Science as an Example

Zhishi guanli luntan, 2019
[Purpose/significance] Scientific data publishing is the main mode of academic communication for data-intensive scientific discovery, which is of great significance for data reuse and scientific verification.
Han Lu, Ding Yi
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source