Results 111 to 120 of about 4,896,525 (280)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tensions et coordinations entre les acteurs des sciences de la performance sportive

Sociologies, 2012
This article is based on a study which examines how knowledge is produced in the field of sports performance, looking at the modes of coordination between researchers and the coaches with whom they collaborate.
Matthieu Delalandre
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Analysis on Articles Published in Nursing Periodicals the Projects That Received Fund Subsidizing

Huli yanjiu, 2002
To understand the status quo of the nursing science research, articles had published in core nursing periodicals including "Chinese Journal of Nursing", "Journal of Nurses Training","Chinese Nursing Research",and"Journal of Practical Nursing" from 1999 ...
李亚琴, 程金莲, 刘雪萍
doaj  

Favorable research environment is a key determinant of research integrity according to a ten-country survey across Central and Eastern Europe

Scientific Reports
Our study was designed to investigate research integrity among scientists actively working in biomedicine. Using the unique opportunity of the Alliance for Life Sciences, a networking initiative of leading research institutions and universities in ...
Renata Veselska, Jan Sirucek, Eugenijus Gefenas, Ana Borovecki, Alliance for Life Focus Group 2: Research Ethics and Research Integrity   +4 more
doaj   +1 more source

SciPub–019–Getting Your Article Published in Scientific Journals- an Event Report

Journal of Multidisciplinary Healthcare, 2020
Nisha Jha, 1 Ranish Shrestha, 2 Sunil Shrestha, 3 Shital Bhandary, 4 Anil Khadka, 5 Pathyil Ravi Shankar 6 1Department of Pharmacology, KIST Medical College, Gwarko, Lalitpur, Nepal; 2Infection Control Unit, Nepal Cancer Hospital and Research Center ...
Jha N, Shrestha R, Shrestha S, Bhandary S, Khadka A, Ravi Shankar P   +5 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Directions for Developing the Efficiency of Scientific Research

Revista Română de Biblioteconomie și Știința Informării, 2019
The article surprises elements of novelty and needs in the activity of scientific research and communication, identifies the needs and their practical settlement.
Ionela Maria Bârsan
doaj