Results 141 to 150 of about 4,871,980 (280)

Pautes del Scientific Council de l'ERC per a l'accés obert (17 de setembre de 2007)

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2008
European Research Council. Scientific Council
doaj  

Complex systems science in the AI era: a pivotal paradigm for scientific research. [PDF]

Natl Sci Rev
Yang M, Zhao W.
europepmc   +1 more source

Scientific Research in Universities [PDF]

Science, 1992
openaire   +2 more sources

Researchers’ perceptions of automating scientific research

AI & SOCIETY
Abstract Science is being transformed by the increasing capabilities of automation technologies and artificial intelligence (AI). Integrating AI and machine learning (ML) into scientific practice requires changing established research methods while maintaining a scientific understanding of research findings.
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mentoring Trainees in This New Scientific Research Landscape: How Can We Help? [PDF]

Cell Mol Gastroenterol Hepatol
Edelblum KL.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The social dimensions of fibromyalgia scientific research: an international classification of functioning, disability, and health-based perspective. [PDF]

Pain Rep
Pontes-Silva A.
europepmc   +1 more source

Scientific Research in Australia [PDF]

Science, 1952
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source