Results 71 to 80 of about 9,241,038 (274)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Penyegaran Tentang Metode Penelitian Ilmiah Untuk Widyaiswara
Scholaria: Jurnal Pendidikan dan Kebudayaan, 2019 Producing a scientific article is one of the requirements that must be met by the Widyaiswara (civil servants who are responsible for doing education and training for other civil servas) to be able achieve higher level of rank and positions.
Yuliana Ria Uli Sitanggang
doaj
Aggregating Scientific Judgment in Scientific Research [PDF]
, 2011 The endeavor to apply the theory of judgment aggregation (TJA) to scientific practice has two main motivating factors. First, this application proceeds from the hope that this new theory could provide a new perspective on well-known problems of the ...
Kunstler, Raphael
core +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
SCIENTOMETRY AND EVALUATION OF THE RESULTS OF ECONOMIC SCIENTIFIC RESEARCH [PDF]
Economica, 2017 Starting from the necessity of a continuous and demanding evaluation, capable of linking the results obtained with the human, material and financial resources, allocated and periodically setting the position of the national research relative to the ...
Ana-Lucia RISTEA +3 more
doaj
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Scientific research, externalities and Economic growth [PDF]
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Erasmo Papagni, Maria Rosaria Carillo
core