Results 41 to 50 of about 1,546,058 (265)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Recognition (to the 175-th anniversary of the birth of V. V. Dokuchaev)
Бюллетень Почвенного института им. В.В. Докучаева, 2021 The article is dedicated to the assessment and the recognition of the merits of V.V. Dokuchaev in different periods. We have divided the stages of the evaluation into three periods, the boundaries of which are taken by the memorable dates since the birth
B. F. Aparin, M. K. Zakharova
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An Introduction to the Scientific Programme of the School
, 1998 It is surprising that the Programme Committee of the Institute has asked me to give an introduction to the programme of this Institute because I am not a member of the Committee. This is the 14th in this series of NATO Advanced Study Institutes, and they are well known for being on areas of research which are both topical and interesting and associated
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
School of English for Political Scientist
Vestnik MGIMO-Universiteta, 2014 Department of English Language № 7 was founded in 2001. Originally its teaching staff included the specialists of the Department of English Language Chair.
Irina A. Mazaeva
doaj
Учёт. Анализ. АудитHaving your own scientific school is an important component of the activities of any scientific team: it forms traditions, fundamental principles and base, and a commonality of views of researchers, acting as the basis for the development of both the ...
O. A. Naumova +2 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source