Results 51 to 60 of about 1,546,058 (265)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Methodology of Modern Rhetorical Education: Russian Scientific Schools

Научный диалог, 2020
The article is devoted to the description of the activities of Russian scientific schools in theoretical and pedagogical understanding of rhetoric as a science of the laws and rules of effective and appropriate speech.
V. I. Annushkin, A. V. Shcherbakov
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

NEW RESEARCH PARADIGMS AND ESTABLISHMENT OF THE UNIVERSITY SCIENTIFIC SCHOOL

Вестник Кемеровского государственного университета, 2013
The paper focuses on the scientific school “Russian literature in the context of Christian culture” at Kemerovo State University, which was established since a new sphere of the literary study in Russia was being developped.
O. V. Pichugina, L. A. Hodanen
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Kazan scientific school of journalism: Definition of paradigmatic boundaries

Ученые записки Казанского университета: Серия Гуманитарные науки, 2017
The paper summarizes the preliminary results, outlines the milestones and the prospects for the formation and development of the Kazan school of journalism.
D.V. Tumanov, A.S. Bik-Bulatov, S.K. Shayhitdinova   +2 more
doaj  

Systems approach in construction—scientific school of a. A. Gusakov (social-communicative survey)

Journal of Civil Engineering and Management, 2003
The scientific school of Academician A. A. Gusakov “Systems engineering in construction” has been approached by a social-communicative model. Scientists belonging to the above school have been identified and the period of the school formation has ...
Edmundas Zavadskas, ArtÅ«ras Kaklauskas   +1 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Scientific School Of Department Of Anesthesiology And Reanimatology [PDF]

Саратовский научно-медицинский журнал, 2009
The article highlights the significant data on scientific school of department of anesthesiology and reanimatology at Saratov State Medical University.
E.B. Kharitonova, I.G. Zhdanov, G.G. Zhdanov   +2 more
doaj