Results 51 to 60 of about 4,153,632 (305)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

“Star of the Russian Musicological Firmament...” The Milestones of Tamara Levaya’s Intellectual Path

open access: yesRussian Musicology
The present article examines the creative path and scholarly ideas of one of the leading Russian musicologists, Doctor of Art History, Tamara Levaya (1938–2025), who for many years headed the Department of Music History at the Glinka Nizhny Novgorod ...
Tatiana B. Sidneva
doaj   +1 more source

Scientific school of academician L.A. Orbeli in Petrograd – Leningrad (to hundredth anniversary of its creation)

open access: yesУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2021
Basic stages of creation, development and spreading of academician L. A. Orbeli scientific school at Petrograd - Leningrad were traced. Significance of main scientific researches of this school in the physiology for the development of adjacent areas of ...
V. V. Kolbanov
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Supernova Educator's Guide [PDF]

open access: yes, 2008
This educator’s guide features three curriculum enhancement activities and one scientific literacy activity, extensive background information, assessment rubrics, student worksheets, extension and transfer activities, and detailed information about the ...

core  

Seeing the natural world: a tension between pupils’ diverse conceptions as revealed by their visual representations and monolithic science lessons [PDF]

open access: yes, 2007
In this paper we report on drawings of the natural environment produced by a sample of 13-14 year-olds. One of our interests is in the extent to which these young people see the world in the way rewarded in science lessons.
Boulter, Carolyn   +2 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Philosophical school of D. V. Pivovarov: current state and development potential

open access: yesИнтеллект. Инновации. Инвестиции
The relevance of the problem being developed is due to the fact that, on the one hand, quite significant attention is paid to the study of philosophical schools in modern literature.
I. A. Belyaev, A. M. Maksimov
doaj   +1 more source

FAMILY DYNASTIES IN THE HISTORY OF RUSSIAN SCIENCE

open access: yesГуманитарные и юридические исследования, 2021
The article deals with scientific dynasties which existed in our country and contributed to the development of its scientific and intellectual potential.
G. Andreychenko, E. Saprykina
doaj  

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