Results 71 to 80 of about 4,153,632 (305)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
National Estuary Program [PDF]
Estuaries are places where rivers meet the sea and are critical to the health of coastal environments and our enjoyment of them. Website features abundant information on the legal and scientific aspects of estuary preservation.
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
NEW RESEARCH PARADIGMS AND ESTABLISHMENT OF THE UNIVERSITY SCIENTIFIC SCHOOL
Вестник Кемеровского государственного университета, 2013 The paper focuses on the scientific school “Russian literature in the context of Christian culture” at Kemerovo State University, which was established since a new sphere of the literary study in Russia was being developped.
O. V. Pichugina, L. A. Hodanen
doaj
, 2001 This is a model for students to assemble, aimed at enhancing their knowledge of NASA spacecraft and scientific facts. The cover of this four-color tri-fold contains background information about the Thermosphere, Ionosphere, Mesosphere Energetics and ...
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Systems approach in construction—scientific school of a. A. Gusakov (social-communicative survey)
Journal of Civil Engineering and Management, 2003 The scientific school of Academician A. A. Gusakov “Systems engineering in construction†has been approached by a social-communicative model. Scientists belonging to the above school have been identified and the period of the school formation has ...
Edmundas Zavadskas +1 more
doaj +1 more source
The Cosmic Ray Observatory Project: A Statewide Outreach and Education Experiment in Nebraska [PDF]
, 2007 The Cosmic Ray Observatory Project (CROP) is a statewide education and research experiment involving Nebraska high school students, teachers and university undergraduates in the study of extensive cosmic-ray air showers.
Claes, Daniel R., Snow, Gregory R.
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Linguametrics as a Form of Life (For the Anniversary of Professor A.D. Deikina) [PDF]
Актуальные проблемы филологии и педагогической лингвистикиThe article is devoted to an iconic figure in Russian methodological science – Honorary Professor of the Moscow State University A.D. Deikina. The contribution of the scientist to the development of the methodology of teaching the Russian language as a ...
Natalya L. Mishatina
doaj +1 more source