Results 71 to 80 of about 1,730,357 (294)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Functional cartography of complex metabolic networks
, 2005 High-throughput techniques are leading to an explosive growth in the size of biological databases and creating the opportunity to revolutionize our understanding of life and disease.
A Arenas +29 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The LIGO Open Science Center [PDF]
, 2015 The LIGO Open Science Center (LOSC) fulfills LIGO's commitment to release, archive, and serve LIGO data in a broadly accessible way to the scientific community and to the public, and to provide the information and tools necessary to understand and use ...
Kanner, Jonah +4 more
core +3 more sources
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
The Soviet doctor and the treatment of drug addiction: "A difficult and most ungracious task"
Harm Reduction Journal, 2011 This paper reviews the development of early Soviet drug treatment approaches by focusing on the struggle for disciplinary power between leading social and mental hygienists and clinical psychiatrists as a defining moment for Soviet drug treatment ...
Latypov Alisher B
doaj +1 more source
Reliable Replication at Low Cost [PDF]
, 2006 The emerging global scientific collaborations demand a scalable, efficient, reliable, and still convenient data access and management scheme. To fulfill these requirements, this paper describes a replicated file system that supports mutable (i.e., read ...
Honeyman, Peter, Zhang, Jiaying
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Data in Brief, 2020 At the Berlin INQUA Congress (1995) a working group, European Late Pleistocene Isotopic Stages 2 & 3: Humans, Their Ecology & Cultural Adaptations, was established under the direction of J.
Pierre M. Vermeersch
doaj +1 more source