Results 161 to 170 of about 3,068,645 (312)
, 2019 “Scientific Work” is apeer-reviewed international scientific journal that publishes high-quality research in the fields of humanities and social sciences, natural sciences, mathematics and mechanics and technical sciences. The journal was registered by the state in 2007 and has been active since that year.
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
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Presenting scientific work-news media theory in presentations, abstracts, and posters. [PDF]
Saudi J Anaesth, 2019 Grech V.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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The Anatomist James Douglas (1675-1742): His Life and Scientific Work. [PDF]
Cureus, 2019 Koutsouflianiotis KN +4 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Work, Professional and Qualification Structure of Scientific Researchers [PDF]
, 1987 U radu se razmatraju neke osnovne dimenzije položaja znanstvenih radnika-istraživača u SR Hrvatskoj, na osnovu rezultata sociološkog istraživanja. U tom se smislu razmatra kvalifikacijska struktura istraživača i njihov profesionalni i radni položaj s ...
Prpić, Katarina, Katarina Prpić
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Development and Preliminary Validation of a New Measure of Values in Scientific Work. [PDF]
Sci Eng Ethics, 2018 English T +3 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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