Results 51 to 60 of about 2,588,444 (261)

Scientific Work

, 2023
The International journal Scientific Work covers all fields of science.
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The department of infectious diseases North-Western State Medical University named after I.I. Mechnikov. From the Past to the Future

Журнал инфектологии, 2014
The history of the department of infectious diseases at North-Western State Medical University named after I.I. Mechnikov since its foundation to the present day is presented in this article.
Yu. V. Lobzin, E. S. Romanova
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Long-term effects of on-the-job skills (mis)match on employee wellbeing and employability: a 7-wave longitudinal study

Frontiers in Psychology
On-the-job skills match, in which employee knowledge and proficiencies (skills) are well-matched with the needs of the job, is often considered more beneficial, both for employees as well as for organizations and society, than a mismatch.
Linda Koopmans, Marieke van den Tooren, Paul Preenen, Paul Preenen   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

MORAL RIGHTS IN THE CASE OF DOCTORAL THESES. LIMITATIONS OF MORAL RIGHTS [PDF]

Challenges of the Knowledge Society
This study attempts an analysis of the doctoral thesis from the perspective of copyright, specifically examining the prerogatives and limitations of copyright when a doctoral thesis is created.
Ionuț Cătălin TIRITEU
doaj  

Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development

Scientific Reports
The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models.
Manuel A. González Hernández, Lars Verschuren, Martien P.M. Caspers, Martine C. Morrison, Jennifer Venhorst, Jelle T. van den Berg, Beatrice Coornaert, Roeland Hanemaaijer, Gerard J. P. van Westen   +8 more
doaj   +1 more source