Results 101 to 110 of about 7,963,700 (296)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Exo-autoethnography : writing and research on transgenerational transmission of trauma
, 2016 Since the late 1970s, autoethnographic research and writing has demonstrated that non-fiction creative writing practice can utilise this alternate-ethnographic method as part of its research and narrative, producing rigorous creative work which is ...
Denejkina, Anna (R19494)
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Writing trauma : affected in the act
, 2013 Writing is an affective process. When the writer writes creatively it is the affective response in the word choice and its resonance for the text's forms and patterns, and other words around it, that determine language use (Freiman 2009: 5).
Michael Richardson +1 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2008 Includes descriptive metadata provided by producer in MP3 file: "The Writing Studio - Podcasts - On-Writing with Cecelia Tichi .
Tichi, Cecelia, 1942-
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2009 This tutorial provides a brief introduction to four key stages of writing at university. Using audio and interactive activities it encourages students to consider their strengths and weaknesses when writing and provides ideas for improving effectiveness.
Skills@Library, University of Leeds +1 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Feisty and childless (a cut and paste; a polylogue)
, 2012 This text results from a research project that analyzed publications about voluntary childlessness, a subject addressed in only a few sociological and psychological texts and almost entirely absent from poetry and fiction.
Smith, Hazel (R11761)
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