Results 131 to 140 of about 7,963,700 (296)
, 2012 A fiction writer will often begin writing a manuscript in a rough and fragmentary manner, and over time transform these early attempts into what is hoped will be a publishable manuscript.
Neave, Lucy (S28838)
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Writing with imagination: A Practical Guide [PDF]
, 2000 Review of Linda Aronson's 'Writing with ...
Bourke, Nicole A.
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
'The Rainbow Bridge': Writing and Teaching in a Regional Context
, 2010 This discussion explores how place shapes the teaching of creative writing. More specifically, the paper considers how creative writing can be taught within a regional context where students may have limited access to literary knowledge, traditions and ...
Green, Stephanie
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Scientific writing: following Robert Boyle\u27s principles in experimental essays -1704 and 1998
, 2007 Science and scientific method have evolved in parallel with changes in philosophical ideas. One aspect of the discipline affected by these changes is the way in which scientists\u27 results should be shown to the world.
Lareo Martín, Inés, Montoya Reyes, Ana
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source