Results 51 to 60 of about 22,137 (302)

Digital spectrometer for prompt fission neutron spectrum measurements

EPJ Web of Conferences, 2017
This paper presents a digital neutron spectrometer based on simultaneous digitizing of the signals from the fission chamber and a scintillation detector. The scintillation detector is based on stilbene crystal.
Prusachenko Pavel, Bondarenko Ivan, Ketlerov Vladimir, Khryachkov Vitaly, Poryvaev Vladislav   +4 more
doaj   +1 more source

Photo-Detectors for Time of Flight Positron Emission Tomography (ToF-PET)

Sensors, 2010
We present the most recent advances in photo-detector design employed in time of flight positron emission tomography (ToF-PET). PET is a molecular imaging modality that collects pairs of coincident (temporally correlated) annihilation photons emitted ...
Craig S. Levin, Virginia Ch. Spanoudaki
doaj   +1 more source

The gas proportional scintillation counter/microstrip gas chamber hybrid detector [PDF]

, 2003
The gas proportional scintillation counter/microstrip gas chamber (GPSC/MSGC) hybrid detector for X-ray spectrometry is described. The detector uses a CsI-coated microstrip plate placed in direct contact with the gas-filling as the photosensor readout ...
Veloso, J. F. C. A., Santos, J. M. F. dos, Conde, C. A. N., Freitas, D. S. A. P., Monteiro, C. M. B.   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

NaI(Tl) Detector Efficiency Computation Using Radioactive Parallelepiped Sources Based on Efficiency Transfer Principle

Science and Technology of Nuclear Installations, 2015
The efficiency transfer (ET) principle is considered as a simple numerical simulation method, which can be used to calculate the full-energy peak efficiency (FEPE) of 3″×3″ NaI(Tl) scintillation detector over a wide energy range.
Mohamed S. Badawi, Mona M. Gouda, Ahmed M. El-Khatib, Abouzeid A. Thabet, Ahmed A. Salim, Mahmoud I. Abbas   +5 more
doaj   +1 more source

The UA2 scintillating fibre detector

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1988
Abstract The UA2 experiment at CERN is currently upgrading its apparatus to take advantage of the higher accelerator luminosity to be provided from November 1987. The first large particle tracking detector using scintillating optical fibres will form a major part of this upgrade. The detector is built by the Cambridge, CERN and Saclay groups.
R.E. Ansorge, C. Anrouet, P. Bareyre, P. Bonamy, C.N. Booth, M. Bouchard, M. Bourdinaud, M. Cordier, J. Crittenden, R.S. Dewolf, J. Dupont, J. Dupraz, K. Einsweiler, C. Engster, J-P. Fabre, J-M. Gaillard, J-L. Garavel, K. Hultqvist, C. Jeanney, S.G. Katvars, M. Lefebvre, L. Linssen, B. McCluskey, B. Merkel, J-P. Meyer, D.J. Munday, P. Nappey, J.M. Pentney, S. Reynaud, J.G. Rushbrooke, J-C. Thevenin, W.Y. Tsang, A.R. Weidberg, P.S. Wells, S.A. Wotton, T.O. White, H. Zaccone   +36 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Investigating the potential of conical scintillation detectors for patient-specific verification of intensity-modulated radiotherapy plans

Physics and Imaging in Radiation Oncology, 2020
Background and purpose: Conical scintillation detectors are frequently used to measure geometric characteristics of radiotherapy modalities. However, their application to verify intensity-modulated radiotherapy plan delivery has not been investigated and
Adam D. Yock, Levi S. Johnson, Michael Price   +2 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source