Results 31 to 40 of about 40,866 (202)

A Whole‐Head Finite Element Model for Electrical Neuromodulation via Visual Brain‐Machine Interfaces

Advanced Science, EarlyView.
A multimodal, personalized head model is presented that integrates the entire visual pathway with surrounding tissues to simulate electrical stimulation of the optic nerve. In vivo validation in humans and goats, plus systematic component‐elimination analysis, demonstrates the high accuracy of the comprehensive model.
Shengjian Lu, Tonghe Yang, Yuan Geng, Huan Wu, Yangrui Huang, Te Zheng, Haodi Chen, Shurui Huang, Yi Cao, Jian Yang, Wentao Yan, Yikui Zhang, Wencan Wu   +12 more
wiley   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Quantitative structural organization of the sclera in chicks after deprivation myopia measured with second harmonic generation microscopy

Frontiers in Medicine
Visual deprivation causes enhanced eye growth and the development of myopia, which is associated with a change in the arrangement of collagen fibers within the sclera.
Juan M. Bueno, Rosa M. Martínez-Ojeda, Enrique J. Fernández, Marita Feldkaemper   +3 more
doaj   +1 more source

Complement factors C1q, C3 and C5b-9 in the posterior sclera of guinea pigs with negative lens-defocused myopia [PDF]

International Journal of Ophthalmology, 2015
AIM:To investigate the expression of complement factors in the posterior scleral fibroblasts of guinea pigs with negative lens-defocused myopia.METHODS:Eighteen guinea pigs were assigned randomly to two groups:the negative lens-defocused group (NLD group,
Ting-Ting Gao, Qin Long, Xue Yang
doaj   +1 more source

Finite Deformation of Scleral Tissue under Electrical Stimulation: An Arbitrary Lagrangian-Eulerian Finite Element Method

Bioengineering, 2023
The sclera is considered as the principal load-bearing tissue within the eye. The sclera is negatively charged; thus, it exhibits mechanical response to electrical stimulation.
Jafar Arash Mehr, Hamed Hatami-Marbini
doaj   +1 more source

ApoE‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration

Animal Models and Experimental Medicine, EarlyView.
Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde, Maite Moreno Orduña, Jaione Bezunartea, Idoia Belza, Ainara Chas, Laura Fernández‐Sánchez, Nicolás Cuenca Navarro, Alfredo García‐Layana, Patricia Fernández‐Robredo, María Hernández   +9 more
wiley   +1 more source

Understanding the spacing of placodes in the eye: A comparative study across age and species

The Anatomical Record, EarlyView.
Abstract The conjunctival placodes of the avian eye form in an intriguing and conserved sequence in a circular annulus around the cornea. These 13–16 placodes develop into papillae that are essential for inducing underlying intramembranous flat bones, known as scleral ossicles, which form an important part of the ocular skeleton.
Florence Joseph, Tamara A. Franz‐Odendaal   +1 more
wiley   +1 more source

Scleral crosslinking with riboflavin and ultraviolet A (UVA). A review

Oftalʹmologiâ, 2016
Crosslinking is a formation of chemical bonds between large molecules. It makes material stronger. Corneal crosslinking with riboflavin and ultraviolet A (UVA) has been successfully used in keratectasia treatment since 2003.
M. M. Bikbov, V. K. Surkova, E. L. Usubov, M. N. Astrelin   +3 more
doaj   +1 more source

Deep Learning Algorithm for Automated Detection of Polycystic Ovary Syndrome Using Scleral Images

Frontiers in Endocrinology, 2022
The high prevalence of polycystic ovary syndrome (PCOS) among reproductive-aged women has attracted more and more attention. As a common disorder that is likely to threaten women’s health physically and mentally, the detection of PCOS is a growing public
Wenqi Lv, Ying Song, Rongxin Fu, Xue Lin, Ya Su, Xiangyu Jin, Han Yang, Xiaohui Shan, Wenli Du, Qin Huang, Hao Zhong, Kai Jiang, Zhi Zhang, Lina Wang, Guoliang Huang, Guoliang Huang   +15 more
doaj   +1 more source

An Ocular Surface‐Targeting Nucleic Acid Hydrogel for Efficient Dry Eye Disease Treatment

Exploration, EarlyView.
A self‐assembled nucleic acid hydrogel modified with mucin‐1 (MUC1) aptamer is developed, which can actively target the mucin layer on the ocular surface and significantly extend its retention time after distillation. Inside the hydrogel, therapeutic siRNA is embedded and can effectively silence the inflammation gene expression, subsequently restoring ...
Yuhe Liu, Zimeng Zhai, Yangyang Huang, Fujun Wang, Zifei Wang, Lijuan Zhu, Ka Jiang, Xujiao Zhou, Xingtao Zhou, Ying Jie, Xiuming Jin, Chuan Zhang, Jiaxu Hong   +12 more
wiley   +1 more source