Results 51 to 60 of about 39,819 (217)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

A Novel Slit Lamp‐Based System for 3D Ultrasound of the Eye

Journal of Ultrasound in Medicine, EarlyView.
Objectives This study aims to develop and evaluate a novel slit‐lamp‐based system to acquire 3‐dimensional (3D) ultrasound volumes using conventional ultrasound probes. Methods A slit‐lamp adapter was 3D printed and connected with a linear actuator and graphical user interface (GUI) system to control movement and create volumes of 2‐dimensional scans ...
Claire E. Malley, Joseph P. Miller, Boyan Pan, Josiah K. To, Jack O. Thomas, Steven Y. Chang, Jason Dagoon, William C. Tang, Parsa Riazi Esfahani, Andrew W. Browne   +9 more
wiley   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

A flexible arched artificial photoreceptor constructed by photodeformable liquid crystal polymers and its application in vision restoration

Smart Molecules, EarlyView.
A flexible arched artificial photoreceptor with high stability and biocompatibility was fabricated by integrating liquid crystal polymers with polyvinylidene fluoride‐trifluoroethylene. This device exhibits robust photoelectric responses under low‐intensity illumination and demonstrates efficacy in restoring visual responses in blind rats following ...
Yumeng Jiang, Bo Peng, Jinyu Ma, Feng Pan, Jia Wei, Lang Qin, Cheng Sun, Yanlei Yu   +7 more
wiley   +1 more source

Biomechanical properties of the sclera in patients with different types of refraction

Офтальмохирургия, 2016
Purpose. To determine biomechanical age-specific features of the scleral tissue and the axial length of the eye.Material and methods. The study investigated 144 isolate d fragments of the sclera of 38 cadaver human eyes at the age from 40 to 75 years ...
E. V. Egorova, S. A. Borzenok, A. N. Bessarabov, A. V. Milingert, M. A. Sevostyanov, A. S. Baikin   +5 more
doaj  

Characterization of retinal pigment epithelium layer in healthy and diseased retinas with high‐resolution adaptive optics transscleral flood illumination imaging

Acta Ophthalmologica, EarlyView.
Abstract Purpose The retinal pigment epithelium (RPE) is critical in the pathophysiology of retinal diseases, such as age‐related macular degeneration. Adaptive optics transscleral flood illumination (AO‐TFI) offers rapid, detailed morphometric characterization of the RPE layer.
Leila Sara Eppenberger, Safa Mohanna, Sohrab Ferdowsi, Sonja Simon‐Zoula, Oliver Pfäffli, Christoph Amstutz, Lucas M. Bachmann, Michael A. Thiel, Martin K. Schmid   +8 more
wiley   +1 more source

Ocular biomechanics study: current state and perspectives

Oftalʹmologiâ, 2015
Despite the fact that the eye represents a challenge for biomechanical research due to its size, over the last two decades, much data on ocular biomechanics were accumulated.
S. Yu. Petrov, V. S. Reshchikova, S. V. Vostrukhin, T. M. Agadzhanyan, N. N. Podgornaya   +4 more
doaj   +3 more sources

Incidence, risk factors, and outcomes of numerical hypotony and choroidal effusion following PRESERFLO MicroShunt implantation

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate the incidence, outcomes, and risk factors of numerical hypotony (NH) and choroidal effusion (CE) following standalone PRESERFLO MicroShunt (PMS) implantation. Methods Primary open‐angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) patients with uni‐ or bilateral surgery at a tertiary university hospital were ...
Emil Nasyrov, Isabel Kommerell, Isabell Schleicher, David A. Merle, Caroline J. Wenzel, Bogomil Voykov   +5 more
wiley   +1 more source

Advances in the genetics of refractive errors: Contributions from the CREAM consortium

Acta Ophthalmologica, EarlyView.
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li, Xi He, Louise Terry, Virginie J. M. Verhoeven, Samantha Sze‐Yee Lee, Gareth Lingham, Jeremy A. Guggenheim, David A. Mackey, Seang‐Mei Saw, Caroline C. W. Klaver, Chi Pui Pang, CREAM Consortium   +11 more
wiley   +1 more source

Axial length, myopia progression, and myopic maculopathy in Stickler syndrome

Acta Ophthalmologica, EarlyView.
Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen, Mette Bertelsen, Nanna D. Rendtorff, Stense Farholt, Line Kessel   +4 more
wiley   +1 more source