Results 111 to 120 of about 1,415,478 (254)

Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression. [PDF]

, 2018
Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions.
Chan, JSK, Chen, J.P., Chiba, S., Koh, NJN, Ng, X.R., Pal, M., Phua, T., Sng, M.K., Tan, C.K., Tan, EHP, Tan, N.S., Teo, Z., Tnay, Y.L., Tong, BMK, Wahli, W., Wang, X., Wee, JWK, Zhu, P.   +17 more
core   +3 more sources

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition

The Journal of Dermatology, EarlyView.
Yoshihide Asano, Jun Asai, Takayuki Ishii, Yohei Iwata, Masanari Kodera, Chie Miyabe, Akihiko Uchiyama, Youichi Ogawa, Ken Okamura, Mari Kishibe, Yuta Koike, Yorihisa Kotobuki, Noriki Fujimoto, Takuya Miyagi, Yukie Yamaguchi, Ayumi Yoshizaki, Reiko Omori, Takeshi Nakanishi, Hiroshi Fujiwara, Takeo Maekawa, Sei‐ichiro Motegi, Yuichiro Yoshino, Minoru Hasegawa, Manabu Fujimoto, Takao Tachibana, Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee (connective tissue disease/vasculitis group)   +27 more
wiley   +1 more source

Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease

ACR Open Rheumatology, Volume 7, Issue 5, May 2025.
Objective Transitioning from pediatric to adult care is challenging for adolescents with chronic health conditions. The Transition Readiness Assessment Questionnaire (TRAQ) is a validated tool for measuring transition readiness in pediatric patients with chronic diseases.
Maryem Al Manaa, Yuhan Ma, Chan‐hee Jo, Una E. Makris, Nicole Bitencourt, Tracey Wright, Lorien Nassi   +6 more
wiley   +1 more source

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. [PDF]

, 2011
OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through ...
Jimenez, Sergio A., Li, zhaodong
core   +2 more sources

Multiple Mucous Cysts on the Hands of a Patient With Systemic Sclerosis Treated With Collagen Sheets for Scar Healing

The Journal of Dermatology, EarlyView.
Takano Hobo, Hiroshi Kato, Shinji Kano, Yukiko Yasui, Maki Yoshimitsu, Motoki Nakamura, Akimichi Morita   +6 more
wiley   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, Volume 12, Issue 19, May 22, 2025.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

Juvenile Localized Scleroderma. Questions of Treatment

Вопросы современной педиатрии, 2020
Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS.
Rinat K. Raupov, Mikhail M. Kostik
doaj   +1 more source

Quantitative nanohistological investigation of scleroderma: An atomic force microscopy-based approach to disease characterization [PDF]

, 2017
Scleroderma (or systemic sclerosis, SSc) is a disease caused by excess crosslinking of collagen. The skin stiffens and becomes painful, while internally, organ function can be compromised by the less elastic collagen.
Aguayo, S, Ahmed, T, Bozec, L, Mordan, N, Parekh, S, Porter, SR, Strange, AP, Stratton, R   +7 more
core   +1 more source

Organoid‐Guided Precision Medicine: From Bench to Bedside

MedComm, Volume 6, Issue 5, May 2025.
This review focuses on the structural and characterization aspects of organoids derived from original cells and scaffold materials. It also examines the construction methodologies, the incorporation of cytokines, and the practical applications in precision medicine.
Boqiang Tao, Xiaolan Li, Ming Hao, Tian Tian, Yuyang Li, Xiang Li, Chun Yang, Qirong Li, Qiang Feng, Hengzong Zhou, Yicheng Zhao, Dongxu Wang, Weiwei Liu   +12 more
wiley   +1 more source