Results 111 to 120 of about 1,480,350 (249)

Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

ACR Open Rheumatology, 2019
Localized scleroderma (LS) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile LS (jLS) cohort from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, a multicenter ...
E. Wu, Suzanne C. Li, K. Torok, Y. Virkud, R. Fuhlbrigge, C. Rabinovich   +5 more
semanticscholar   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Juvenile Localized Scleroderma. Questions of Treatment

Вопросы современной педиатрии, 2020
Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS.
Rinat K. Raupov, Mikhail M. Kostik
doaj   +1 more source

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. [PDF]

, 1996
Mice carrying the Tight skin (Tsk) mutation have thickened skin and visceral fibrosis resulting from an accumulation of extracellular matrix molecules.
Buchberg, Arthur M., Christner, Paul J., Jimenez, Sergio A., Ma, Qing, Manne, Jayanthi, McGrath, Rodney, Moskow, John J., Siracusa, Linda D.   +7 more
core   +3 more sources

Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma

Journal of Rheumatology, 2019
Objective. To perform a comparative effectiveness feasibility study in juvenile localized scleroderma (LS), using standardized treatment regimens (consensus treatment plans; CTP). Methods.
Suzanne C. Li, K. Torok, C. Rabinovich, F. Dedeoğlu, M. Becker, P. Ferguson, Sandy D. Hong, M. Ibarra, K. Stewart, E. Pope, G. Higgins, R. Laxer, T. Mason, R. Fuhlbrigge, Tracy Andrews   +14 more
semanticscholar   +1 more source

A Patient with Localized Scleroderma Successfully Treated with Etretinate

Case Reports in Dermatology, 2014
There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed. We encountered a case who was treated successfully with etretinate, a vitamin A derivative.
Tomoko Shima, Yuki Yamamoto, Takaharu Ikeda, Fukumi Furukawa   +3 more
doaj   +1 more source

Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis [PDF]

, 2005
Transforming growth factor-beta (TGF-beta) plays a crucial role in the pathogenesis of skin fibrotic diseases. Systemic TGF-beta inhibitors effectively inhibit fibrosis in different animal models; however, systemic inhibition of TGF-beta raises important
Borras-Cuesta, F. (Francisco), Dotor, J. (Javier), Gutierrez-Cañas, I. (Irene), Lasarte, J.J. (Juan José), Pablos, J.L. (José L.), Palao, G. (Guillermo), Prieto, J. (Jesús), Ruiz, J. (Juan), Santiago, B. (Begoña)   +8 more
core  

MicroRNA in localized scleroderma: a review of literature

Archives of Dermatological Research, 2019
Localized scleroderma (LoSc) is rare connective tissue disease that manifests with inflammation and fibrosis of the skin. Depending on the LoSc subtype, adjacent structures such as subcutaneous tissue, fascia, muscles, bones may be affected. The hallmark
Katarzyna Wolska-Gawron, J. Bartosińska, D. Krasowska   +2 more
semanticscholar   +1 more source

Recent Advances in Localized Scleroderma

Sclerosis
Localized scleroderma (LSc), or morphea, is an autoimmune connective tissue disease causing inflammation and fibrosis of the skin and underlying tissues. While distinct from systemic sclerosis, its clinical presentation is highly diverse.
Toshiya Takahashi, Takehiro Takahashi, Yoshihide Asano   +2 more
doaj   +1 more source

Reliability of LoSCAT score for activity and tissue damage assessment in a large cohort of patients with Juvenile Localized Scleroderma

Pediatric Rheumatology Online Journal, 2018
Objectives To assess reliability of the two indexes of Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), the modified Localized Scleroderma Skin Severity Index (mLoSSI) and the Localized Scleroderma Skin Damage Index (LoSDI), when applied by ...
Anna Agazzi, Gloria Fadanelli, Fabio Vittadello, Francesco Zulian, Giorgia Martini   +4 more
doaj   +1 more source