Results 111 to 120 of about 1,428,643 (254)

Internal Involvement in Localized Scleroderma

Medicine, 1994
We studied 76 consecutive patients with localized scleroderma (morphea with or without linear scleroderma) and analyzed the frequency, prognosis, and predictors of internal involvement in a subset of 53 patients systematically investigated for the presence of such involvement.
Anne Cosnes, Jean-Claude Roujeau, Laure Dehen, Jean Revuz   +3 more
openaire   +3 more sources

Quality of Life and Optimism in Patients with Morphea [PDF]

, 2013
Despite extensive knowledge about quality of life of people suffering from dermatological diseases, data on patients with morphea are scarce. The aim of our study was to compare the quality of life of healthy controls and morphea patients, as well as to ...
Aleksandra Dańczak-Pazdrowska, Aleksandra Szewczyk, Anna Sadowska-Przytocka, Beata Szramka-Pawlak, Ryszard Żaba, Teresa Rzepa   +5 more
core   +1 more source

Scleroderma-Like Lupus Panniculitis: A Case Report and Literature Review

Clinical, Cosmetic and Investigational Dermatology, 2023
Prinpat Pinyowiwat, Suthinee Rutnin, Kumutnart Chanprapaph Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kumutnart Chanprapaph, Division of Dermatology ...
Pinyowiwat P, Rutnin S, Chanprapaph K
doaj  

Niosomal Hydrogel Loaded With Bromelain: A Promising Solution for Reducing Skin Collagen in Scleroderma Patients

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Skin fibrosis in scleroderma is a chronic and debilitating condition that affects the quality of life of patients. In this study, we fabricated a niosomal hydrogel containing bromelain to reduce skin collagen and improve skin softness in scleroderma patients.
Hanieh Ardeshiri, Mina Ghorbani, Mohammad Ali Nazarinia, Kimia Falamarzi, Ali Mohammad Tamaddon, Negar Azarpira   +5 more
wiley   +1 more source

Hyaluronic Acid Filler Injection for Localized Scleroderma – Case Report and Review of Literature on Filler Injections for Localized Scleroderma

Clinical, Cosmetic and Investigational Dermatology, 2022
Jaishree Sharad Skinfiniti Aesthetic Skin and Laser Clinic, Mumbai, Maharashtra, IndiaCorrespondence: Jaishree Sharad, Skinfiniti Aesthetic Skin and Laser Clinic, 601, Prabhat Chambers, Khar West, S.V.Road, Mumbai, Maharashtra, 400052, India, Tel ...
Sharad J
doaj  

Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α Inhibition

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
The second messenger cyclic AMP (cAMP) dedifferentiates pathologic lung and skin myofibroblasts derived from patients with scleroderma by inhibiting the MAPK p38α. Though cAMP has anti‐fibrotic effects in fibroblasts from both organs, the cellular capacity to generate cAMP in response to the canonical stimulus prostaglandin E2 (PGE2) is substantially ...
Jared D. Baas, John Varga, Carol Feghali‐Bostwick, Marc Peters‐Golden, Sean M. Fortier   +4 more
wiley   +1 more source

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

Disturbed Spatial WNT Activation—A Potential Driver of the Reticularized Skin Phenotype in Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 6, Page 740-749, June 2025.
Objective Little is known on the mechanisms necessary to maintain the physiologic adult human skin integrity. This study aims to quantitatively describe anatomic changes in systemic sclerosis (SSc)–skin compared with controls and investigate the underlying mechanisms.
Sara Chenguiti Fakhouri, Honglin Zhu, Yi‐Nan Li, Moritz Ronicke, Aleix Rius Rigau, Clara Dees, Laura Konstantinidis, Ralf Schmid, Alexandru‐Emil Matei, Markus Eckstein, Carol Geppert, Ingo Ludolph, Alexander Kreuter, Michael Sticherling, Carola Berking, Raymund E. Horch, Georg Schett, Jörg H. W. Distler, Christina Bergmann   +18 more
wiley   +1 more source

Narrowing Down Key Players in Autoimmunity via Single‐Cell Multiomics

European Journal of Immunology, Volume 55, Issue 6, June 2025.
This review explores how single‐cell sequencing and multiomics reveal cell states and communication networks involved in autoimmunity. We highlight insights into antigen specificity and autoreactive lymphocytes, uncovering mechanisms like molecular mimicry.
Altea Gjurgjaj, Cecilia Domínguez Conde
wiley   +1 more source

Сучасні аспекти патогенетичної терапії хворих на склеродермію. Огляд літератури [PDF]

, 2015
Дані літератури свідчать, що традиційні лікарські препарати у хворих на склеродермію ефективні далеко не завжди; багато з них спричиняють різні побічні реакції, що обумовлює пошук принципово нових терапевтичних технологій, у тому числі – з використанням ...
Горбунцов, В.В., Романенко, В.Н., Романенко, К.В.   +2 more
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