Results 111 to 120 of about 1,472,132 (249)
Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics
Development, Growth &Differentiation, Volume 67, Issue 9, Page 487-499, December 2025.ABSTRACT Throughout our lifespan, sustaining orderly morphological structures for ensuring proper functioning of organs is imperative. Among these structures, the extracellular matrix (ECM) plays a pivotal role in sustaining organ and tissue homeostasis. Nevertheless, elucidating the role of abnormal ECM‐induced biomechanical microenvironmental changes
Hirotaka Tao
wiley +1 more source
Juvenile Localized Scleroderma. Questions of Treatment
Вопросы современной педиатрии, 2020 Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS.
Rinat K. Raupov, Mikhail M. Kostik
doaj +1 more source
Advanced Science, Volume 12, Issue 41, November 6, 2025.Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun +13 more
wiley +1 more source
ACR Open Rheumatology, 2019 Localized scleroderma (LS) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile LS (jLS) cohort from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, a multicenter ...
E. Wu +5 more
semanticscholar +1 more source
Clinical pattern of systemic sclerosis in Central Ukraine. Association between clinical manifestations of systemic sclerosis and hypertension [PDF]
, 2018 Objectives: Systemic sclerosis (SSc) is a rare disease of connective tissue, manifestations of which may vary in different geographical areas. We aimed to describe the clinical portrait of patients with SSc in Dnipropetrovsk region and to investigate how
Kuryata, O., Lysunets, T., Semenov, V.
core +1 more source
A Patient with Localized Scleroderma Successfully Treated with Etretinate
Case Reports in Dermatology, 2014 There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed. We encountered a case who was treated successfully with etretinate, a vitamin A derivative.
Tomoko Shima +3 more
doaj +1 more source
Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis [PDF]
, 2005 Transforming growth factor-beta (TGF-beta) plays a crucial role in the pathogenesis of skin fibrotic diseases. Systemic TGF-beta inhibitors effectively inhibit fibrosis in different animal models; however, systemic inhibition of TGF-beta raises important
Borras-Cuesta, F. (Francisco) +8 more
core
Lidocaine for systemic sclerosis: a double-blind randomized clinical trial [PDF]
, 2011 Background: Systemic sclerosis (scleroderma; SSc) is an orphan disease with the highest case-specific mortality of any connective-tissue disease. Excessive collagen deposit in affected tissues is a key for the disease's pathogenesis and comprises most of
Andrade, Luis E. C. +5 more
core +2 more sources
Pansclerotic Morphea with Features of Eosinophilic Fasciitis: Distinct Entities or Part of a Continuum? [PDF]
, 2014 Scleroderma is a highly complex disorder in its clinical manifestations and pathogenesis. It has a wide range of clinical manifestations due to varying degrees of vasculopathy, autoimmunity, altered endothelium function, and abnormal fibrosis.
Canty, Kristi +2 more
core +1 more source
Dermatology Review, 2019 Localized scleroderma (morphea) is a chronic autoimmune disease of the connective tissue. Its etiopathogenesis is unknown. Most often the disease affects the skin, but may also involve the subcutis, muscles, and the osteoarticular system.
D. Krasowska +10 more
semanticscholar +1 more source