Results 71 to 80 of about 274,582 (186)

Estimating AutoAntibody Signatures to Detect Autoimmune Disease Patient Subsets [PDF]

arXiv, 2017
Autoimmune diseases are characterized by highly specific immune responses against molecules in self-tissues. Different autoimmune diseases are characterized by distinct immune responses, making autoantibodies useful for diagnosis and prediction. In many diseases, the targets of autoantibodies are incompletely defined.
arxiv  

Assessing the Health Implications of UV/LED Nail Lamp Radiation Exposure During Manicure and Pedicure Procedures: A Scoping Review

International Journal of Dermatology, Volume 64, Issue 4, Page 659-666, April 2025.
ABSTRACT Skin malignancies associated with radiation exposure, notably malignant melanoma and keratinocyte carcinoma, are emerging as a significant global health challenge. While indoor tanning beds are associated with skin cancer risk, limited research exists on ultraviolet (UV)/light‐emitting diode (LED) nail lamps used widely in manicures/pedicures.
Dmitry Beylin, Rachel Kornhaber, Danielle Le Lagadec, Michelle Cleary   +3 more
wiley   +1 more source

Internal Involvement in Localized Scleroderma

Medicine, 1994
We studied 76 consecutive patients with localized scleroderma (morphea with or without linear scleroderma) and analyzed the frequency, prognosis, and predictors of internal involvement in a subset of 53 patients systematically investigated for the presence of such involvement.
Anne Cosnes, Jean-Claude Roujeau, Laure Dehen, Jean Revuz   +3 more
openaire   +3 more sources

A Bayesian Approach to Restricted Latent Class Models for Scientifically-Structured Clustering of Multivariate Binary Outcomes [PDF]

arXiv, 2018
In this paper, we propose a general framework for combining evidence of varying quality to estimate underlying binary latent variables in the presence of restrictions imposed to respect the scientific context. The resulting algorithms cluster the multivariate binary data in a manner partly guided by prior knowledge.
arxiv  

A hybrid protein is a functional molecule to reduce the cytokine storm caused by excessively activated macrophages

Immunology &Cell Biology, Volume 103, Issue 4, Page 350-364, April 2025.
In this article, we have developed a hybrid protein, tentatively named human MIKO‐1 (hMIKO‐1). The messenger RNA expression of each proinflammatory cytokine was significantly suppressed by hMIKO‐1 despite a subsequent stimulation with lipopolysaccharide. hMIKO‐1 is a functional molecule that significantly attenuates the cytokine storm.
Masaki Ikemoto, Takuya Kotani, Kohki Okada, Shogo Matsuda, Tohru Takeuchi   +4 more
wiley   +1 more source

Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background CD47 could negatively regulate macrophage‐mediated phagocytosis and contribute to senescent cells accumulation in aging. However, it remains unknown whether CD47 is overexpressed in photoaged skin and involved in photoaging pathogenesis.
Xinya Xu, Xinhua Lu, Xinling Chen, Amin Yao, Wei Lai   +4 more
wiley   +1 more source

A Patient with Localized Scleroderma Successfully Treated with Etretinate

Case Reports in Dermatology, 2014
There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed. We encountered a case who was treated successfully with etretinate, a vitamin A derivative.
Tomoko Shima, Yuki Yamamoto, Takaharu Ikeda, Fukumi Furukawa   +3 more
doaj   +1 more source

Systemic Sclerosis Dermal Fibroblast Exosomes Trigger Type 1 Interferon Responses in Keratinocytes via a TBK/JAK/STAT Signaling Axis

Arthritis &Rheumatology, Volume 77, Issue 3, Page 322-334, March 2025.
Objective Activation of type I interferon (IFN) response has been shown to correlate with disease activity in systemic sclerosis (SSc). It is currently unknown whether the tissue‐specific type I IFN activation is a consequence of the response observed in blood or rather its source.
Jessica Bryon, Christopher W. Wasson, Katja Koeppen, Francesca Chandler, Leon F. Willis, Stefano Di Donato, Elliott Klein, Elton Zeqiraj, Rebecca L. Ross, Francesco Del Galdo   +9 more
wiley   +1 more source

Reliability of LoSCAT score for activity and tissue damage assessment in a large cohort of patients with Juvenile Localized Scleroderma

Pediatric Rheumatology Online Journal, 2018
Objectives To assess reliability of the two indexes of Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), the modified Localized Scleroderma Skin Severity Index (mLoSSI) and the Localized Scleroderma Skin Damage Index (LoSDI), when applied by ...
Anna Agazzi, Gloria Fadanelli, Fabio Vittadello, Francesco Zulian, Giorgia Martini   +4 more
doaj   +1 more source

Locally Compact Contractive Local Groups [PDF]

arXiv, 2009
We study locally compact contractive local groups, that is, locally compact local groups with a contractive pseudo-automorphism. We prove that if such an object is locally connected, then it is locally isomorphic to a Lie group. We also prove a related structure theorem for locally compact contractive local groups which are not necessarily locally ...
arxiv