Results 91 to 100 of about 1,261,715 (219)

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

A Comprehensive Review of Acne Treatments: Unpacking the Chemical Structures and Effective Bioactive Compounds

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari, Setare Abolghasemi, Elham Khanniri, Maryam Bayanati, Rahil Hakimimofrad, Mohammad Mahboubi‐Rabbani   +5 more
wiley   +1 more source

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

MedComm, Volume 7, Issue 2, February 2026.
Increased miR‐3163 targets NUDT21, reducing CPSF5 levels and driving APA dysregulation. This results in 3′UTR shortening of CBFB, which stabilizes RUNX1 and promotes smooth muscle proliferation. PTGER3, is also shortened amplifying hypoxia‐induced RVSP. Together, these pathways contribute to vascular remodeling in PH. Image Created in https://BioRender.
Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty‐Quintana   +17 more
wiley   +1 more source

Bosentan Does Not Affect Renal Resistive Index in Scleroderma/Systemic Sclerosis Patients.

Kidney Blood Press Res, 2023
Di Poi E, Colussi G, Bertoni M, Giovannini I, Tolusso B, Ferraccioli GF, Gremese E, De Vita S, Romano G.   +8 more
europepmc   +1 more source

European Dermatology Forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes

Journal of the European Academy of Dermatology and Venereology, 2017
R. Knobler, P. Moinzadeh, Nicolas Hunzelmann, A. Kreuter, A. Cozzio, L. Mouthon, M. Cutolo, F. Rongioletti, C. Denton, L. Rudnicka, L. A. Frasin, V. Smith, A. Gabrielli, E. Aberer, M. Bagot, G. Bali, J. Bouaziz, A. Olesen, I. Foeldvari, C. Francès, A. Jalili, U. Just, V. Kähäri, S. Kárpáti, K. Kofoed, D. Krasowska, M. Olszewska, C. Orteu, J. Panelius, Andrea Parodi, A. Petit, P. Quaglino, A. Ranki, J. M. Schmidt, J. Seneschal, A. Skrok, M. Sticherling, C. Sunderkötter, Alain Taïeb, A. Tanew, P. Wolf, M. Worm, N. Wutte, T. Krieg   +43 more
semanticscholar   +1 more source

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu, Zhi‐Ping Jin, Shu‐Qiang Weng, Ji‐Min Zhu, Ling Dong   +4 more
wiley   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
wiley   +1 more source

A Rare Case of Juvenile Systemic Sclerosis: Clinical Challenges and Management

Annals of Rheumatology and Autoimmunity
Scleroderma is “skleros” sclerosing or hardening of the “derma” skin. It includes both systemic and localized scleroderma (LS). Mostly, juvenile LS affects the skin, whereas juvenile systemic sclerosis (SSc) involves multiple organ systems.
Areej Bano, Shalini Verma, Shrish Bhatnagar   +2 more
doaj   +1 more source

New‐onset autoimmune disease following SARS‐CoV‐2 infection and mRNA vaccination in Norway: A retrospective cohort study

Journal of Internal Medicine, Volume 299, Issue 2, Page 271-282, February 2026.
Abstract Background Studies suggest an increase in autoimmune diseases following SARS‐CoV‐2 infection and/or COVID‐19‐vaccination. We aimed to describe possible associations in Norway. Methods We used information from the emergency preparedness register for COVID‐19, BeredtC19, for all residents aged 18–64 (N = 3,450,080).
Håkon Bøås, Paz Lopez‐Doriga Ruiz, Jesper Dahl, Hanne L. Gulseth, German Tapia   +4 more
wiley   +1 more source

Working under Pressure: Scleroderma Presenting with Bilateral Exudative Retinal Detachment in the Context of Scleroderma Renal Crisis: A Case Report

Case Reports in Ophthalmology
This is an observational case report to detail a novel case of scleroderma renal crisis presenting as bilateral exudative retinal detachments in a patient with newly diagnosed systemic sclerosis.
Rem Aziz, Cody Lo, James T. Denstedt, Bernard Hurley   +3 more
doaj   +1 more source