Results 141 to 150 of about 893,246 (219)

Association of Childhood Acute Leukemia With Autoimmune Diseases

International Journal of Cancer, Volume 159, Issue 5, Page 1188-1195, 1 September 2026.
A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka, Julia Ventelä, Anssi Auvinen, Olli Lohi, Atte Nikkilä   +4 more
wiley   +1 more source

Case Report: Scleroderma Renal Crisis Presenting as Thrombotic Microangiopathy

Turkish Journal of Nephrology, 2019
Scleroderma is a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in multiple organs. It can cause thrombotic microangiopathy.
Mehmet Can UĞUR, Ferhat EKİNCİ, Tuğba KARADENİZ, Elif GRAM, Hülya ÇOLAK, Cengiz CEYLAN, Harun AKAR   +6 more
doaj  

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 655-666, September 2026.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

JEADV Clinical Practice, Volume 5, Issue 3, Page 917-921, September 2026.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, Volume 270, Issue 1, Page 98-113, September 2026.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen, Samu Luostarinen, Ida Valjus, Julia Vistbacka, Antti Pemmari, Eeva Moilanen   +5 more
wiley   +1 more source

Oral and Periodontal Manifestations in Systemic Sclerosis: A Comprehensive Review of Pathophysiology, Clinical Features, and Management Strategies. [PDF]

Oral Health Prev Dent
Meer R.
europepmc   +1 more source

Multiple External Invasive Root Resorption and Calcification in Systemic Sclerosis—Case Report

International Endodontic Journal, Volume 59, Issue 9, Page 1963-1978, September 2026.
ABSTRACT Aim There are few reports in the literature of multiple external invasive root resorption (EIRR) lesions in patients with systemic sclerosis (SSc), and an association between root resorption and SSc is not well established. We report the only case that comprehensively illustrates—with the combination of histopathology, cone beam computed ...
Jee‐Yun Leung, Geoffrey Heithersay, Richard Logan, Sharon Liberali   +3 more
wiley   +1 more source

Scleroderma.

, 2009
Scleroderma (systemic sclerosis) is a complex disease in which extensive fibrosis, vascular alterations, and autoantibodies against various cellular antigens are among the principal features There are two major subgroups in the commonly accepted ...
Gabrielli A., AVVEDIMENTO, VITTORIO ENRICO, AVVEDIMENTO EV, GABRIELLI, ARMANDO, Krieg T.   +4 more
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