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SYSTEMIC SCLEROSIS (SCLERODERMA)
Acta Clinica Belgica, 2007Systemic sclerosis is a rare and often debilitating disorder characterized by a pathological triad: increased deposition of extracellular matrix and collagen in tissues, microvascular damage and dysfunction, and immune activation as evidenced by inflammation and frequent occurrence of autoantibodies.
Roufosse, Florence +1 more
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The fascia in systemic scleroderma
Journal of the American Academy of Dermatology, 1980Diffuse fasciitis (DF) shares clinical and pathologic features with systemic (SS) and localized scleroderma. The distinct pathologic feature in DF is involvement of the deep fascia, but it is not known if these changes consistently occur in SS. In this study, ten patients with SS underwent deep biopsies for evaluation of the fascia.
Miguel Vázquez Botet, Jorge L. Sánchez
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Migraine and Systemic Scleroderma
Archives of Dermatology, 1978Scleroderma with typical migraine headaches occurred in 16 well-documented cases observed over a 25-year period. Although the number of cases is within the expected range of coincidence of both diseases, in 13 of the 16 patients the scleroderma developed after 15 years or more of therapy with ergot or methysergide preparations.
Richard K. Winkelmann +2 more
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Systemic and localized scleroderma
Clinics in Dermatology, 2006Sclerosing conditions of the skin are manifested by a full spectrum of presentations that includes skin-limited forms as well as those which can involve internal organs and result in death. At this point, we are just beginning to understand the mechanisms of tissue fibrosis, and it is likely that the fibrotic processes are a heterogeneous group of ...
Lorinda Chung +3 more
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