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The Medical clinics of North America, 2010 Scleroderma encompasses a wide variety of diseases, including localized scleroderma, overlap syndromes, sclerodermoid conditions, and systemic scleroderma. This article emphasizes the systemic scleroderma.
Jennyy Sun +3 more
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The Lancet Rheumatology, 2021
BACKGROUND Preliminary criteria for the very early diagnosis of systemic sclerosis (VEDOSS) have been previously proposed to identify signs and symptoms in patients with Raynaud's phenomenon.
S. Bellando-Randone +14 more
semanticscholar +1 more source
BACKGROUND Preliminary criteria for the very early diagnosis of systemic sclerosis (VEDOSS) have been previously proposed to identify signs and symptoms in patients with Raynaud's phenomenon.
S. Bellando-Randone +14 more
semanticscholar +1 more source
SYSTEMIC SCLEROSIS (SCLERODERMA)
Acta Clinica Belgica, 2007Systemic sclerosis is a rare and often debilitating disorder characterized by a pathological triad: increased deposition of extracellular matrix and collagen in tissues, microvascular damage and dysfunction, and immune activation as evidenced by inflammation and frequent occurrence of autoantibodies.
Roufosse, Florence +1 more
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Systemic Scleroderma with Linear Scleroderma.
Nishi Nihon Hifuka, 200253歳の女性にみられた線状強皮症を伴った全身性強皮症の1例を報告した。1975年頃より間質性肺炎と手指の硬化があり,当院呼吸器科で全身性強皮症としてプレドニンの内服治療を受けていた。数年前より手指の硬化が著明になると共に前胸部に皮下硬結を自覚。数ヵ月前より皮下硬結の延長が認められたため当科を受診した。初診時,前胸部に淡紅色の線状を呈する皮下硬結が認められた。血液検査所見では,抗核抗体が320倍と陽性,KL-6も643 U/mlと上昇していた。胸部X線·CT像では,間質性肺炎が認められた。前胸部の皮下硬結よりの皮膚生検で真皮の膠原線維の増生と真皮血管周囲の軽度リンパ球浸潤がみられた。以上の所見より,線状強皮症を伴った全身性強皮症と診断した ...
Mahiro YAMAMURA +2 more
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Medical Clinics of North America, 1989
Scleroderma encompasses a wide variety of diseases, including localized scleroderma, overlap syndromes, sclerodermoid conditions, and systemic scleroderma. This article emphasizes the systemic scleroderma.
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Scleroderma encompasses a wide variety of diseases, including localized scleroderma, overlap syndromes, sclerodermoid conditions, and systemic scleroderma. This article emphasizes the systemic scleroderma.
openaire +2 more sources
Scleroderma in Children and Adolescents: Localized Scleroderma and Systemic Sclerosis.
The Pediatric clinics of North America, 2018Scleroderma is a rare disease that has two main forms: localized scleroderma (LS) and systemic sclerosis (SSc). Both are chronic diseases, can present in different patterns (subtypes), and are associated with extracutaneous involvement in pediatric ...
Suzanne C. Li
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Current Rheumatology Reports, 2001
Systemic scleroderma in children is very rare and is considered similar to adult-onset disease. In adults, new etiopathogenetic and therapeutic approaches have emerged in recent years. For instance, it has been shown that microchimerism could play a role in disease pathogenesis and that immunoablation followed by stem cell rescue could be of potential ...
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Systemic scleroderma in children is very rare and is considered similar to adult-onset disease. In adults, new etiopathogenetic and therapeutic approaches have emerged in recent years. For instance, it has been shown that microchimerism could play a role in disease pathogenesis and that immunoablation followed by stem cell rescue could be of potential ...
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Systemic Sclerosis, Scleroderma
2006Abstract The scleroderma spectrum of disorders includes several diseases that have Raynaud’s phenomenon or skin sclerosis in common, comprising (1) localized cutaneous scleroderma; (2) systemic sclerosis (SSc)—the most important form of scleroderma—limited cutaneous SSc, diffuse cutaneous SSc, and overlap syndromes (with features of ...
Christopher P. Denton, Carol M. Black
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