Results 141 to 150 of about 56,983 (273)
Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern".
Autoimmunity Reviews, 2019 V. Smith +18 more
semanticscholar +1 more source
Clinical Case Reports, Volume 13, Issue 4, April 2025.ABSTRACT AKE and cutis laxa type ARCL1A are both disorders of elastic fibers characterized histologically by elastin degeneration and/or fragmentation. However, the pathogenesis is thought to be distinct. AKE is an autosomal dominant disorder with an unknown gene mutation.
Sumayyah I Alrefaie +6 more
wiley +1 more source
Diverse potential of chimeric antigen receptor‐engineered cell therapy: Beyond cancer
Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.1. In theory, CAR‐engineering therapy can achieve therapeutic effects by targeting cells expressing specific antigens and thereby eliminating or regulating disease‐related cell subpopulations. 2. Although CAR‐engineering therapy is currently only approved for the treatment of cancer, it has also shown potential in non‐tumour diseases. 3.
Lvying Wu, Lingfeng Zhu, Jin Chen
wiley +1 more source
Probiotic Interventions in Systemic Sclerosis Patients: A Systematic Review and Future Prospects
Health Science Reports, Volume 8, Issue 4, April 2025.ABSTRACT Background and Aims Systemic sclerosis (SSc) is an uncommon autoimmune connective tissue disease distinguished by fibrosis and vascular abnormalities, often leading to gastrointestinal problems. This review explores the potential of probiotics in managing SSc‐related gastrointestinal issues and modulating immune responses, highlighting the ...
Zahra Mirfeizi +4 more
wiley +1 more source
Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.This study investigates the risk of serious infections (SIs) in patients treated with biologic or targeted‐synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) in Qatar. Out of 1092 patients, 86 (7.9%) experienced SIs, with adalimumab and infliximab associated with higher SI rates.
Sreethish Sasi +12 more
wiley +1 more source
Learning Health Systems, Volume 9, Issue 2, April 2025.Abstract Introduction (1) Assess the harmonization of structured electronic health record data (laboratory results and medications) to reference terminologies and characterize the severity of issues. (2) Identify issues of data completeness by comparing complementary data domains, stratifying by time, care setting, and provenance.
Keith Marsolo +14 more
wiley +1 more source
The Peptide PROTAC Modality: A New Strategy for Drug Discovery
MedComm, Volume 6, Issue 4, April 2025.Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley +1 more source
Pediatric Blood &Cancer, Volume 72, Issue 4, April 2025.ABSTRACT Background Systemic inflammatory diseases (SIDs) have been reported in patients with sickle cell disease (SCD), but clinical data in children are scarce. Objectives To identify clinical and laboratory features at diagnosis of SID in children with SCD and to describe their evolution.
Caroline Vinit +19 more
wiley +1 more source
Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension
Pulmonary Circulation, Volume 15, Issue 2, April 2025.ABSTRACT Cellular communication network 2 (CCN2) is a secreted matricellular protein associated with pulmonary arterial hypertension (PAH) but has not been studied relative to PAH severity, outcomes, or right ventricle (RV) structure and function in a large human cohort and preclinical animal model. This study assessed the associations between CCN2 and
Carly E. Byrd +19 more
wiley +1 more source