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Immunology, Volume 177, Issue 4, Page 736-748, April 2026.A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
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New England Journal of Medicine, 2009
Scleroderma (systemic sclerosis) is a complex disease in which extensive fibrosis, vascular alterations, and autoantibodies against various cellular antigens are among the principal features There are two major subgroups in the commonly accepted classification of scleroderma: limited cutaneous scleroderma and diffuse cutaneous scleroderma.
Gabrielli A. +2 more
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Scleroderma (systemic sclerosis) is a complex disease in which extensive fibrosis, vascular alterations, and autoantibodies against various cellular antigens are among the principal features There are two major subgroups in the commonly accepted classification of scleroderma: limited cutaneous scleroderma and diffuse cutaneous scleroderma.
Gabrielli A. +2 more
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Rheumatic Disease Clinics of North America, 1989
This article reviews the literature on scleroderma and pregnancy, highlighting its sparsity, confused state, and retrospective nature. It emphasizes the need for more informed prospective work. This is required for clinical management and to help understand the complex interaction between scleroderma and pregnancy.
C M, Black, W M, Stevens
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This article reviews the literature on scleroderma and pregnancy, highlighting its sparsity, confused state, and retrospective nature. It emphasizes the need for more informed prospective work. This is required for clinical management and to help understand the complex interaction between scleroderma and pregnancy.
C M, Black, W M, Stevens
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Current Opinion in Rheumatology, 2006
Localized scleroderma, also known as morphoea, has a variety of clinical manifestations that can include systemic involvement. Early recognition, diagnosis and treatment may improve the long-term outcome.A large multicentre study coordinated by the Pediatric Rheumatology European Society has yielded important information on the epidemiology and ...
Ronald M, Laxer, Francesco, Zulian
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Localized scleroderma, also known as morphoea, has a variety of clinical manifestations that can include systemic involvement. Early recognition, diagnosis and treatment may improve the long-term outcome.A large multicentre study coordinated by the Pediatric Rheumatology European Society has yielded important information on the epidemiology and ...
Ronald M, Laxer, Francesco, Zulian
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Best Practice & Research Clinical Rheumatology, 1995
In practice, the classification of scleroderma is less problematic than that of most other connective tissue diseases given the distinctive pattern of skin involvement. Classification of early and limited disease is more problematic and is difficult to separate from severe forms of Raynaud's phenomenon. Division of scleroderma into two groups depending
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In practice, the classification of scleroderma is less problematic than that of most other connective tissue diseases given the distinctive pattern of skin involvement. Classification of early and limited disease is more problematic and is difficult to separate from severe forms of Raynaud's phenomenon. Division of scleroderma into two groups depending
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Scleroderma (sect. Scleroderma) sect. Scleroderma
Published as part of Yang, Kun L., Lin, Jia Y., Li, Guang-Mei & Yang, Zhu L., 2025, Updates of Scleroderma (Basidiomycota, Boletales): new data from 18 selected species in China, pp.Yang, Kun L. +3 more
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Journal of the American Academy of Dermatology, 1987
After a review of some pathogenetic and pathologic aspects of scleroderma, the experimental effects of a group of agents that can inhibit the formation of connective tissue, especially the biosynthesis of collagen, are mentioned. These substances were transferred to clinical therapy of scleroderma.
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After a review of some pathogenetic and pathologic aspects of scleroderma, the experimental effects of a group of agents that can inhibit the formation of connective tissue, especially the biosynthesis of collagen, are mentioned. These substances were transferred to clinical therapy of scleroderma.
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Clinical and experimental dermatology, 2003
A 53-year-old woman with systemic sclerosis developed numerous cutaneous nodules, resembling keloids, on her anterior chest wall. The nodules failed to respond to therapy with topical steroid, calcipotriol, or extended photochemotherapy. This is a rare, disfiguring variant of scleroderma, unresponsive to treatment, and poorly understood.
Ling, T. C. +4 more
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A 53-year-old woman with systemic sclerosis developed numerous cutaneous nodules, resembling keloids, on her anterior chest wall. The nodules failed to respond to therapy with topical steroid, calcipotriol, or extended photochemotherapy. This is a rare, disfiguring variant of scleroderma, unresponsive to treatment, and poorly understood.
Ling, T. C. +4 more
openaire +4 more sources