Results 41 to 50 of about 95,141 (285)

A Case Report of Systemic Sclerosis Complicated by Biventricular Heart Failure, Pulmonary Hypertension and Review of Literature [PDF]

, 2017
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder whose aetiology is not fully understood. Skin fibrosis and visceral organs involvement are the hallmarks, and the heart could be disproportionately or subtly involved ...
Akinboro AO, Akinlade M, Akintunde AA, Audu MB   +3 more
core   +1 more source

Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database

Drugs - Real World Outcomes, 2023
Background Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ.
Maria Maddalena Nicoletti, Erminia Crisci, Vincenzo Cosenza, Consiglia Riccardi, Maria Rosaria Campitiello, Donatella Ruggiero, Pasquale Maria Berrino, Giovanni Docimo, Cristina Scavone   +8 more
doaj   +1 more source

Antineutrophil cytoplasmic antibody-associated vasculitis in a patient with diffuse scleroderma

Indian Journal of Rheumatology, 2021
Scleroderma is a multiorgan connective tissue disease characterized by autoantibody production and fibroproliferative stenosis of the microvasculature. The development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in patients with ...
B N Shiva Prasad, H A Karthik Urala
doaj   +1 more source

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis [PDF]

, 2014
In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested.
, Airó, Paolo, Alarcón-Riquelme, Marta, AlKassab, Firas, Arnett, Frank C., Assassi, Shervin, Baron, Murray, Beretta, Lorenzo, Bossini-Castillo, Lara, Broen, Jasper, Brown, Matthew, Carmona, Francisco David, Carreira, Patricia, Castellví, Iván, Chen, Wei V., Denton, Christopher, Distler, Jörg H.W., Docherty, Peter, Fessler, Barri J., Fonseca, Carmen, Frech, Tracy M., Furst, Daniel E., González-Gay, Miguel Ángel, Gorlova, Olga, Gregersen, Peter K., Guerra, Sandra, Herrick, Ariane, Hesselstrand, Roger, Hinchcliff, Monique E., Hudson, Marie, Hummers, Laura K., Hunzelmann, Nicolas, Jones, Henry Niall, Kaminska, Elzbieta, Khalidi, Nader, Khanna, Dinesh, Koeleman, Bobby P., Kreuter, Alexander, Lafyatis, Robert A., Lee, Annette T., Lunardi, Claudio, López-Isac, Elena, Markland, Janet, Martin, Javier, Martin, José Ezequiel, Mayes, Maureen D., Molitor, Jerry A., Nordin, Annika, Ochoa, Eguzkine, Padyukov, Leonid, Phillips, Kristin, Pope, Janet E., Radstake, Timothy R.D.J., Reveille, John D., Riemekasten, Gabriela, Robinson, David, Schiopu, Elena, Schuerwegh, Annemie J., Segal, Barbara M., Shiels, Paul, Silver, Richard M., Simeón, Carmen Pilar, Simms, Robert W., Steen, Virginia D., Tan, Filemon K., Teruel, María, van Laar, Jacob M., Varga, John, Voskuyl, Alexandre E., Wigley, Fredrick M., Wijmenga, Cisca, Witte, Torsten, Worthington, Jane, Ying, Jun, Zhernakova, Alexandra, Zhou, Xiaodong   +75 more
core   +1 more source

Juvenile Localized Scleroderma from the Perspective of Pediatric Rheumatologist. Aspects of Diagnostics

Вопросы современной педиатрии, 2020
The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of ...
Rinat K. Raupov, Artur I. Imelbaev, Mikhail M. Kostik   +2 more
doaj   +1 more source

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort [PDF]

, 2010
<p><b>Objectives</b> The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features.</p> <p><b>Methods</b> A total of 8 European ...
A E Voskuyl, A Fernández-Nebro, A Herrick, A J Schuerwegh, A Kreuter, A Nordin, A Pros, B A Lie, B P Koeleman, B Rueda, C Denton, C Fonseca, C P Simeon, C Tolosa, E De Langhe, E Vicente-Rabaneda, F De Keyser, F Houssiau, F J García-Hernández, G Espinosa, G Riemekasten, H Manku, I Castellví, I Gómez-Gracia, J A Román-Ivorra, J M van Laar, J Martín, J Worthington, JCA Broen, K Claes, L Beretta, L Bossini-Castillo, L Padykov, L Rodríguez, M A González-Gay, M C Vonk, M F González-Escribano, M Gallego, M M Chee, M T Camps, M V Egurbide, MJ Gough, MJH Coenen, N Hunzelmann, N Navarrete, N Ortego-Centeno, P Airó, P Carreira, P García de la Peña, P Gourh, P Shiels, R Hesselstrand, R Madhok, R Scorza, R Westhovens, T Witte, TRDJ Radstake, V Follonosa, V Smith, Ø Palm   +59 more
core   +5 more sources

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma

Frontiers in Immunology, 2021
Microvascular injury is considered an initial event in the pathogenesis of scleroderma and endothelial cells are suspected of being the target of the autoimmune process seen in the disease. EBV has long been proposed as a trigger for autoimmune diseases,
Antonella Farina, Edoardo Rosato, Michael York, Benjamin E. Gewurz, Benjamin E. Gewurz, Benjamin E. Gewurz, Maria Trojanowska, Giuseppina Alessandra Farina   +7 more
doaj   +1 more source

Eosinophilic fasciitis (Shulman's disease): review and comparative evaluation of seven patients. [PDF]

, 2019
OBJECTIVES: Eosinophilic fasciitis (EF) was described in 1974 by Shulman as a rare fibrosing connective tissue disease of unknown etiology. An undetermined trigger is thought to lead to the degranulation of eosinophils that interact with fibroblasts and
Cimbron, M, Farinha, F, Mendonça, T, Urzal, J   +3 more
core   +1 more source

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source