Results 51 to 60 of about 80,483 (293)
Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis
iScience, 2021 Summary: The processes underlying synchronous multiple organ fibrosis in systemic sclerosis (SSc) remain poorly understood. Age-related pathologies are associated with organismal decline in nicotinamide adenine dinucleotide (NAD+) that is due to ...
Bo Shi +20 more
doaj
Arthritis Research & Therapy, 2017 Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only.
Marco Matucci-Cerinic +7 more
doaj +1 more source
Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? [PDF]
PLoS ONE, 2008 Scleroderma is an autoimmune disease with a characteristic vascular pathology. The vasculopathy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease.We used immunohistochemical and mRNA in situ ...
Jo N Fleming +12 more
doaj +1 more source
Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]
, 2016 Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M +6 more
core +1 more source
Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. [PDF]
, 2008 OBJECTIVE: Recent studies have implicated caveolin 1 in the regulation of transforming growth factor beta (TGFbeta) downstream signaling. Given the crucial role of TGFbeta in the pathogenesis of systemic sclerosis (SSc), we sought to determine whether ...
de Almeida, Cecilia J. +6 more
core +2 more sources
Mucosal‐Associated Invariant T Cells in Rheumatic Diseases
Arthritis &Rheumatology, EarlyView.Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek +7 more
wiley +1 more source
SCLERODERMA AND SCLERODACTYLY [PDF]
The Journal of Nervous and Mental Disease, 1920 n ...
openaire +4 more sources
Prognostic Factors of Renal Involvement in Systemic Sclerosis [PDF]
, 2018 Background/Aims: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was
Barbano, Biagio +5 more
core +2 more sources
Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database
Drugs - Real World Outcomes, 2023 Background Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ.
Maria Maddalena Nicoletti +8 more
doaj +1 more source
Epidemiology of scleroderma. [PDF]
Annals of the Rheumatic Diseases, 1991 The rarity of scleroderma makes it a difficult disorder to study epidemiologically. Recent studies have highlighted some of the environmental exposures associated with the disease. Among occupational exposures silica remains the most important, whereas appetite suppressants might be an important drug cause. The disease also appears to cluster in space,
openaire +5 more sources