Results 51 to 60 of about 2,859 (161)

Scleroderma renal crisis: pathogenesis issues, disease pattern and modern approaches to the treatment

Počki, 2018
Scleroderma renal crisis (SRC) is a major complication in patients with systemic sclerosis. SRC occurs in about 5–25 % of all patients with scleroderma. It is characterized by malignant hypertension and olig-/anuric acute renal failure.
I.Yu. Golovach, Ye.D. Yehudina
doaj   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Features and Prognosis of Patients With Retroperitoneal Fibrosis Developing Fibrosing Mediastinitis: Case‐Control Study and Systematic Review

ACR Open Rheumatology, Volume 7, Issue 8, August 2025.
Objective Retroperitoneal fibrosis (RPF) complicated by mediastinal fibrosis (MF) is rare but fatal. We aimed to explore the features and indicators of poor prognosis for the population of those affected. Methods Patients with idiopathic RPF were recruited in Peking University International Hospital.
Yishan Ding, Zhiyan Li, Shibo Liu, Mei Li, Yubo Ren, Kai‐Feng Xu, Chenghua Luo, Cuiping Pan, Hui Gao   +8 more
wiley   +1 more source

Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Scleromyxedema is an uncommon, chronic connective tissue disorder with an obscure etiology. It is distinguished by fibromyxoid skin lesions and elevated serum monoclonal immunoglobulin levels. The condition's rarity limits epidemiological data, making prevalence and incidence assessment difficult.
Shanshan Liang, Jingjing Zeng, Peiying Zhong, Chengyao Jia, Li Zhang   +4 more
wiley   +1 more source

Scleroderma Renal Crisis Debute with Thrombotic Microangiopathy: A Successful Case Treated with Eculizumab

Case Reports in Nephrology, 2018
We had the challenged to treat a 40-year-old female with Systemic Scleroderma who was showing unspecific symptoms. During her time at the hospital she rapidly develops renal dysfunction, associated with hypertension.
Maite Hurtado Uriarte, Carolina Larrarte, Laura Bravo Rey   +2 more
doaj   +1 more source

French recommendations for the management of systemic sclerosis

Orphanet Journal of Rare Diseases, 2021
Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and microvessels, characterized by the appearance of fibrosis and vascular obliteration.
Eric Hachulla, Christian Agard, Yannick Allanore, Jerome Avouac, Brigitte Bader-Meunier, Alexandre Belot, Alice Berezne, Anne-Sophie Bouthors, Geraldine Condette-Wojtasik, Joël Constans, Pascal De Groote, Elisabeth Diot, Florence Dumas, Patrick Jego, Francisca Joly, David Launay, Veronique Le Guern, Janine-Sophie Le Quintrec, Geraldine Lescaille, Christophe Meune, Bruno Moulin, Christelle Nguyen, Nadine Omeish, Frederic Pene, Marie-Aleth Richard, Juliette Rochefort, Alexandra Roren, Olivier Sitbon, Vincent Sobanski, Marie-Elise Truchetet, Luc Mouthon, Collaborators   +31 more
doaj   +1 more source

Critical Role for Transglutaminase 2 in Scleroderma Skin Fibrosis and in the Development of Dermal Sclerosis in a Mouse Model of Scleroderma

Arthritis &Rheumatology, Volume 77, Issue 7, Page 914-928, July 2025.
Objective Scleroderma is a life‐threatening autoimmune disease characterized by inflammation, tissue remodeling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally induced dermal fibrosis to determine its potential role and therapeutic implications.
Angela Y. Y. Tam, Korsa Khan, Shiwen Xu, Marianne Bergin, Linghong Huang, Erik Arroyo Colon, Danyi Cheng, Elisabetta A. M. Verderio, Voon Ong, Christopher P. Denton, John Atkinson, Tim S. Johnson, David J. Abraham   +12 more
wiley   +1 more source

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 929-941, July 2025.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

Recurrent Takotsubo Cardiomyopathy With Variable Patterns and Psychiatric Comorbidities: A Case Report and Comprehensive Literature Review

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Takotsubo cardiomyopathy (TTC) is a transient stress‐induced cardiac syndrome that can mimic acute coronary syndrome but typically lacks obstructive coronary disease. We report a case of a 50‐year‐old woman with complex psychiatric comorbidities who developed classical apical TTC following acute emotional distress—distinct from a prior reverse
Hamza AlKowatli, Oubada Alkowatli, Ahmad Karzoun, Bisher Sawaf, Mhd Baraa Habib, Nahush Bansal, Muhammad Faiz, Robert Subbiondo   +7 more
wiley   +1 more source

A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma

Case Reports in Rheumatology, 2016
Systemic sclerosis is a rare autoimmune disorder with a wide spectrum of clinical manifestations and a multitude of autoantibodies that are associated with it.
Cody M. Lee, Diana Girnita, Arundhati Sharma, Surabhi Khanna, Jean M. Elwing   +4 more
doaj   +1 more source