Results 61 to 70 of about 680,317 (306)

Beyond Raynaud's: Atypical Peripheral Vascular Manifestations in a Case of CREST Syndrome

open access: yesClinical Case Reports
Peripheral vascular disease (PVD) is a rare but severe symptom of CREST syndrome, which itself is a limited cutaneous sclerosis. Even though Raynaud's phenomenon is the gold standard of CREST, the development of critical limb ischemia and self‐amputation
Sakshi Kumari   +4 more
doaj   +1 more source

Tibial deformities caused by focal fibrocartilaginous dysplasia: a narrative review

open access: yesFrontiers in Pediatrics
Focal fibrocartilaginous dysplasia (FFCD) of the tibia is a rare but well-recognised, “tumour-like” condition that primarily involves the proximal tibia and causes tibial deformities.
Dimitri Fasel   +9 more
doaj   +1 more source

EndoTHeF: Endoluminal Treatment of Hemorrhoids with Foam [PDF]

open access: yesIranian Journal of Colorectal Research, 2018
Background: Hemorrhoids are normal anatomical structures, present in individuals from birthandrecognisable even in intrauterinelife. When we talk about haemorrhoids in actual fact we refer to the symptoms caused by haemorrhoids.
Maurizio Ronconi   +2 more
doaj  

Hematopoietic Cell Transplantation for Systemic Sclerosis—A Review

open access: yesCells, 2022
Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease associated with significant morbidity and mortality. Conventional immunosuppressive therapies demonstrate limited efficacy.
Daniel Levin   +11 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen   +7 more
wiley   +1 more source

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

open access: yes, 2013
Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV with intact ...
Turnbull, Doug M   +5 more
core   +1 more source

Ultraviolet A1 Phototherapy for Fibrosing Conditions

open access: yesFrontiers in Medicine, 2018
In this article we describe efficacy and safety aspects of ultraviolet A1 (UV-A1) phototherapy in fibrosing conditions. UV-A1 is a specific phototherapeutic modality that is defined by a selective spectral range (340–400 nm).
Thilo Gambichler, Lutz Schmitz
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich   +19 more
wiley   +1 more source

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis [PDF]

open access: yes, 2011
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability.
Myhr, K. M.   +999 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

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